930547

Pomalidomide-PEG₁-C₂-azide

≥95.0%

• Sinônimo(s): 1H-Isoindole-1,3(2H)-dione, 4-[[2-(2-azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl), 4-((2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxopiperidin-3-yl]isoindoline-1,3-dione, 4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
• Fórmula empírica (Notação de Hill): C₁₇H₁₈N₆O₅
• Número CAS: 2271036-44-1
• Peso molecular: 386.36
• Código UNSPSC: 12352125
• NACRES: NA.21

Propriedades

• ligand: pomalidomide
• Nível de qualidade: 100
• Ensaio: ≥95.0%
• forma: powder
• grupo funcional: azide
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: [N-]=[N+]=NCCOCCNC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3

Descrição

Aplicação

Pomalidomide-PEG₁-C₂-azide is a functionalized cereblon ligand for development of pomalidomide-based PROTACs. Contains an alkyne, allowing for conjugation through click chemistry. A basic building block for development of a protein degrader library.

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Outras notas

Targeted Protein Degradation by Small Molecules

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Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable