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53530

Sigma-Aldrich

DL-Homocysteine thiolactone hydrochloride

≥99.0% (AT)

Sinônimo(s):

DL-2-Amino-4-mercaptobutyric acid 1,4-thiolactone hydrochloride

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About This Item

Fórmula empírica (Notação de Hill):
C4H7NOS · HCl
Número CAS:
6038-19-3
Peso molecular:
153.63
Beilstein:
3689338
Número CE:
227-923-3
Número MDL:
MFCD00012724
Código UNSPSC:
12352100
eCl@ss:
42021308
ID de substância PubChem:
57651419
NACRES:
NA.22

Nível de qualidade

200

Ensaio

≥99.0% (AT)

forma

solid

perda

≤0.5% loss on drying

pf

202 °C (dec.) (lit.)
~203 °C (dec.)

cadeia de caracteres SMILES

Cl[H].NC1CCSC1=O

InChI

1S/C4H7NOS.ClH/c5-3-1-2-7-4(3)6;/h3H,1-2,5H2;1H

chave InChI

ZSEGSUBKDDEALH-UHFFFAOYSA-N

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Descrição geral

DL-Homocysteine thiolactone hydrochloride (HTL-HCl) is a cyclic amino acid derivative that exhibits root-growth inhibitory activity.

Aplicação

DL-Homocysteine thiolactone hydrochloride may be used in the preparation of:
  • DL-buthionine
  • DL-homocysteine
  • poly[α,β-(N-2-aminoethyl-dl-aspartamide)]-poly[α,β-(N-2-hydroxyethyl-dl-aspartamide)]-poly[α,β-(N-3-mercapto-1-methoxycarbonyl-propyl-dl-aspartamide)] copolymer diclofenac conjugate (PAHMA-Dic)
  • bis[ S-(dimethylarsino)homocysteine]

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H315,H319

Declarações de precaução

P302 + P352 - P305 + P351 + P338

Classificações de perigo

Eye Irrit. 2 - Skin Irrit. 2

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Sigma-Aldrich

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Jerott R Moore et al.
Journal of neuroimmunology, 324, 100-114 (2018-09-30)
We investigated how one calcitriol dose plus vitamin D3 reverses experimental autoimmune encephalomyelitis (EAE), a multiple sclerosis model. This protocol rapidly increased CD4+ T cell Ikzf2 transcripts, Helios protein, and CD4+Helios+FoxP3+ T regulatory cells. It also rapidly increased CD4+ T
Joanna Malinowska et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(11), 4023-4027 (2012-08-18)
Elevated concentration of homocysteine (Hcy) in human plasma, defined as hyperhomocysteinemia has been correlated with some diseases, such as cardiovascular, neurodegenerative, and kidney disorders. Homocysteine occurs in human plasma in several forms, including the most reactive form of Hcy -
Lukasz Marczak et al.
Journal of proteomics, 74(7), 967-974 (2011-02-19)
Elevated levels of homocysteine (Hcy) are associated with cardiovascular and neurodegenerative diseases in humans. Hcy becomes a component of human proteins as a result of N-homocysteinylation of protein lysine residues by Hcy-thiolactone, which affects the protein's structure and function, and
Reza Yousefi et al.
International journal of biological macromolecules, 51(3), 291-298 (2012-05-29)
In the current study both structural alteration and fibrillation of insulin were studied in the presence of homocysteine thiolactone (HCTL). The spectroscopic studies revealed that HCTL increases rate of insulin unfolding, giving rise to the appearance of solvent-exposed hydrophobic regions
Joanna Malinowska et al.
Platelets, 22(4), 277-283 (2011-05-12)
Resveratrol (3,4',5-trihydroxystilben), a phenolic antioxidant synthesized in grapes and other plants, and also present in wine, has been suggested to help prevent cardiovascular events. In this study the influence of resveratrol on platelet aggregation during a model of hyperhomocysteinemia was
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