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Merck

RRM2B

ribonucleotide reductase M2 B (TP53 inducible)

Sinônimos:
MTDPS8A, MTDPS8B, P53R2
Espécies:
ID UniProtKB:
ID do gene:
  • Human(50484) Summary: This gene encodes the small subunit of a p53-inducible ribonucleotide reductase. This heterotetrameric enzyme catalyzes the conversion of ribonucleoside diphosphates to deoxyribonucleoside diphosphates. The product of this reaction is necessary for DNA synthesis. Mutations in this gene have been associated with autosomal recessive mitochondrial DNA depletion syndrome, autosomal dominant progressive external ophthalmoplegia-5, and mitochondrial neurogastrointestinal encephalopathy. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2010]
  • Mouse(382985) ribonucleotide reductase M2 B (TP53 inducible)
  • Rat(299976) ribonucleotide reductase M2 B (TP53 inducible)
  • cow(528960) ribonucleotide reductase M2 B (TP53 inducible)
  • sheep(101123639) ribonucleotide reductase M2 B (TP53 inducible)
  • naked mole-rat(101718446) ribonucleotide reductase M2 B (TP53 inducible)
  • domestic guinea pig(100715485) ribonucleotide reductase M2 B (TP53 inducible)
  • Zebrafish(368909) ribonucleotide reductase M2 b
  • chicken(420253) ribonucleotide reductase M2 B (TP53 inducible)
  • Horse(100062030) ribonucleotide reductase M2 B (TP53 inducible)
  • domestic cat(101099777) ribonucleotide reductase M2 B (TP53 inducible)
  • dog(481988) ribonucleotide reductase M2 B (TP53 inducible)

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Antibodies

Número do produto
Descrição
Reatividade de espécies
Aplicação
Anti-RRM2B antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reatividade de espécies
human
Aplicação
immunofluorescence
immunohistochemistry
Anti-P53R2 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Reatividade de espécies
human, mouse, rat
Aplicação
ELISA
immunofluorescence

immunohistochemistry

western blot
Monoclonal Anti-RRM2B antibody produced in mouse, clone 6C1, ascites fluid,
Reatividade de espécies
human
Aplicação
ELISA
western blot

Small Molecule - Inhibitor

Número do produto
Descrição
Espécies
Hydroxycarbamide, British Pharmacopoeia (BP) Reference Standard,
Espécies
human
Hydroxyurea, 98%, powder,
Espécies
human
Gemcitabine hydrochloride, ≥98% (HPLC),
Espécies
human
Clofarabine, ≥98% (HPLC),
Espécies
human

esiRNA

Número do produto
Descrição
Espécies
MISSION® esiRNA, targeting human RRM2B,
Espécies
human