CALR
calreticulin
Sinônimos:
CRT, RO, SSA, cC1qR
Espécies:
Human CALR (811), Mouse Calr (12317), Rat Calr (64202), Zebrafish calr (30248), Zebrafish calr (100332662), cow CALR (281036), domestic cat CALR (101087384), dog CALR (476694), domestic guinea pig Calr (100713922), naked mole-rat Calr (101719263) ...Mais
ID UniProtKB:
ID do gene:
- Human(811) Summary: Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes. [provided by RefSeq, Jul 2008]
- Mouse(12317) calreticulin
- Rat(64202) calreticulin
- Zebrafish(30248) calreticulin
- Zebrafish(100332662) calreticulin
- cow(281036) calreticulin
- domestic cat(101087384) calreticulin
- dog(476694) calreticulin
- domestic guinea pig(100713922) calreticulin
- naked mole-rat(101719263) calreticulin
- sheep(101104396) calreticulin
- Domestic Rabbit(100009050) calreticulin
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Antibodies
Número do produto
Descrição
Reatividade de espécies
Aplicação
Anti-Calreticulin antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Reatividade de espécies
canine, human
Aplicação
immunofluorescence
immunoprecipitation (IP)
microarray
western blot
immunoprecipitation (IP)
microarray
western blot
Monoclonal Anti-Calreticulin antibody produced in mouse, clone TO-11, tissue culture supernatant, buffered aqueous solution,
Reatividade de espécies
human
Aplicação
ELISA
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
Anti-Calreticulin Antibody, clone 1F16 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reatividade de espécies
horse, human, monkey, mouse, rat
Aplicação
affinity binding assay
immunocytochemistry
western blot
immunocytochemistry
western blot
Anti-Calreticulin Antibody, clone 16B11.1, clone 16B11.1, from mouse,
Reatividade de espécies
human
Aplicação
flow cytometry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-CALR antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reatividade de espécies
human, mouse, rat
Aplicação
immunohistochemistry
western blot
western blot