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Merck

ABAT

4-aminobutyrate aminotransferase

Sinônimos:
GABA-AT, GABAT, NPD009
Espécies:
Human ABAT (18), Mouse Abat (268860), Rat Abat (81632), Zebrafish abat (378968), cow ABAT (280969), Horse ABAT (100051470), domestic cat ABAT (101089064), dog ABAT (479856), chicken ABAT (416642), naked mole-rat Abat (101712584) ...Mais
ID UniProtKB:
P80404, A8K386, Q16260, Q8N5W2, Q96BG2, Q99800
ID do gene:
  • Human(18) Summary: 4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(268860) 4-aminobutyrate aminotransferase
  • Rat(81632) 4-aminobutyrate aminotransferase
  • Zebrafish(378968) 4-aminobutyrate aminotransferase
  • cow(280969) 4-aminobutyrate aminotransferase
  • Horse(100051470) 4-aminobutyrate aminotransferase
  • domestic cat(101089064) 4-aminobutyrate aminotransferase
  • dog(479856) 4-aminobutyrate aminotransferase
  • chicken(416642) 4-aminobutyrate aminotransferase
  • naked mole-rat(101712584) 4-aminobutyrate aminotransferase
  • domestic guinea pig(100725419) 4-aminobutyrate aminotransferase
  • Goat(100861058) 4-aminobutyrate aminotransferase
  • sheep(101105462) 4-aminobutyrate aminotransferase

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Antibodies

Número do produto
Descrição
Reatividade de espécies
Aplicação
HPA041690
Anti-ABAT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reatividade de espécies
human
Aplicação
immunohistochemistry
western blot
HPA041528
Anti-ABAT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reatividade de espécies
human
Aplicação
immunohistochemistry
western blot
SAB2100006
Anti-ABAT antibody produced in rabbit, affinity isolated antibody,
Reatividade de espécies
bovine, dog, goat, guinea pig, human, mouse, rabbit, rat
Aplicação
western blot
SAB5702893
Anti-GABA transaminase (ABAT) Antibody, clone 10V1K9, Rabbit Monoclonal, ,
Reatividade de espécies
human, rat
Aplicação
immunohistochemistry
western blot

esiRNA

Número do produto
Descrição
Espécies
EMU217131
MISSION® esiRNA, targeting mouse Abat,
Espécies
mouse
EHU001161
MISSION® esiRNA, targeting human ABAT,
Espécies
human
EMU015101
MISSION® esiRNA, targeting mouse Abat,
Espécies
mouse