- In vitro immunomodulation of splenocytes from DO11.10 mice by the food colouring agent amaranth.
In vitro immunomodulation of splenocytes from DO11.10 mice by the food colouring agent amaranth.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (2017-11-07)
David E Lefebvre, Nikia Ross, Andrea L Kocmarek, Simon Cowell, Shelley Dai, Cunye Qiao, Ivan Curran, Terry Koerner, Genevieve S Bondy, Jason H Fine
PMID29107027
ABSTRACT
The chemical amaranth (AM) is permitted as a colouring agent in a variety of foods. Safety was established based on chronic rodent studies. AM and its metabolite naphthionic acid (NA) can be absorbed through the intestine, exposing circulating immune cells including splenocytes. An AM feeding study in rats demonstrated an increase in blood lymphocytes. Yet, in contrast, AM inhibited the delayed-type hypersensitivity reaction to antigen. DO11.10 mice express a T Cell Receptor specific for ovalbumin
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