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Merck

PRG2

proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)

Synonyms:
BMPG, MBP, MBP1
Species:
Human PRG2 (5553), Mouse Prg2 (19074), Rat Prg2 (58826), Horse PRG2 (100062803)
UniProtKB ID:
P13727, P81448, Q14227, Q6ICT2
Gene ID:
  • Human(5553) Summary: The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
  • Mouse(19074) proteoglycan 2, bone marrow
  • Rat(58826) proteoglycan 2, bone marrow
  • Horse(100062803) proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)

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Antibodies

Product Number
Description
Species Reactivity
Application
HPA038515
Anti-PRG2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
CBL419
Anti-Eosinophil Major Basic Protein Antibody, clone BMK13, clone BMK13, Chemicon®, from mouse,
Species Reactivity
human
Application
ELISA
immunohistochemistry
western blot
ABS1675
Anti-PXDN/VPO1 Antibody, from rabbit, purified by affinity chromatography,
Species Reactivity
bovine, human, mouse
Application
immunohistochemistry
immunoprecipitation (IP)
western blot

esiRNA

Product Number
Description
Species
EHU045031
MISSION® esiRNA, targeting human PRG2,
Species
human