HTT
huntingtin
Synonyms:
HD, IT15
Species:
Human HTT (3064), Mouse Htt (15194), Rat Htt (29424), Zebrafish htt (30214), fruit fly htt (43392), chicken HTT (422878), domestic cat HTT (101086476), cow HTT (615059), dog HTT (479074), domestic guinea pig Htt (100713322)
UniProtKB ID:
Gene ID:
- Human(3064) Summary: Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range in the number of trinucleotide repeats has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression. [provided by RefSeq, Jul 2008]
- Mouse(15194) huntingtin
- Rat(29424) huntingtin
- Zebrafish(30214) huntingtin
- fruit fly(43392) huntingtin
- chicken(422878) huntingtin
- domestic cat(101086476) huntingtin
- cow(615059) huntingtin
- dog(479074) huntingtin
- domestic guinea pig(100713322) huntingtin
- naked mole-rat(101697599) huntingtin
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Polyglutamines antibody, Mouse monoclonal, ~2 mg/mL, clone 3B5H10, purified from hybridoma cell culture,
Species Reactivity
human
Application
immunocytochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-HTT antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-Huntingtin Antibody, a.a. 115-129 Antibody, clone 5HU-1H6, ,
Species Reactivity
human
Application
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-Serotonin Transporter Antibody, 1 mg/mL, from rabbit,
Species Reactivity
bovine, chimpanzee, horse, human, monkey, mouse, rat, sheep
Application
western blot
Anti-Huntingtin, from rabbit, purified by affinity chromatography,
Species Reactivity
human, mouse
Application
immunohistochemistry
western blot
western blot