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Merck

HSPG2

heparan sulfate proteoglycan 2

Synonyms:
HSPG, PLC, PRCAN, SJA, SJS, SJS1
Species:
UniProtKB ID:
Gene ID:
  • Human(3339) Summary: This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and Transthyretin, etc. and plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and Tardive dyskinesia.[provided by RefSeq, Mar 2010]
  • Mouse(15530) perlecan (heparan sulfate proteoglycan 2)
  • Rat(117511) heparan sulfate proteoglycan 2
  • Zebrafish(565429) heparan sulfate proteoglycan 2
  • cow(444872) heparan sulfate proteoglycan 2
  • Horse(100071701) heparan sulfate proteoglycan 2
  • domestic cat(101094520) heparan sulfate proteoglycan 2
  • dog(403440) heparan sulfate proteoglycan 2
  • chicken(429806) heparan sulfate proteoglycan 2
  • sheep(101122677) heparan sulfate proteoglycan 2
  • Domestic Rabbit(100340334) heparan sulfate proteoglycan 2
  • sheep(100294588) heparan sulfate proteoglycan 2
  • domestic guinea pig(100718406) heparan sulfate proteoglycan 2
  • naked mole-rat(101700294) heparan sulfate proteoglycan 2

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ELISA

Product Number
Description
Species
Human Endorepellin ELISA, for serum, plasma and cell culture supernatants,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Heparan Sulfate Proteoglycan (Perlecan) Antibody, clone A7L6, clone A7L6, from rat,
Species Reactivity
human
Application
immunocytochemistry
immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-Heparan Sulfate Proteoglycan (Perlecan) Antibody, clone 5D7-2E4, clone 5D7-2E4, from mouse,
Species Reactivity
human
Application
immunocytochemistry
immunohistochemistry

western blot
Anti-HSPG2 Antibody, clone 1M17 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, rat
Application
affinity binding assay
immunocytochemistry

immunohistochemistry

western blot
Anti-HSPG2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
Anti-Estrogen Receptor Antibody, clone B10, ascites fluid, clone B10, Chemicon®,
Species Reactivity
human, rat
Application
ELISA
immunohistochemistry

western blot

Proteins

Product Number
Description
Species
ECM Gel from Engelbreth-Holm-Swarm murine sarcoma, growth-factor reduced, without phenol red, liquid, BioReagent, suitable for cell culture,
Species
mouse

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Hspg2,
Species
mouse
MISSION® esiRNA, targeting human HSPG2,
Species
human