- Treatment of a tongue lymphangioma with sirolimus after failure of surgical resection and propranolol.
Treatment of a tongue lymphangioma with sirolimus after failure of surgical resection and propranolol.
Pediatric blood & cancer (2013-11-23)
Canan Akyüz, Erman Ataş, Ali Varan
PMID24265139
RÉSUMÉ
Lymphangiomas of the tongue are rare, and their treatment is problematic. A 10 year-old patient with tongue lymphangioma who was previously treated with surgery and propranolol with no response was treated with sirolimus in our department. We used sirolimus with a dose of 1.6 mg/m(2)/day. After 3 months of treatment, the mass had decreased by more than 60%. We continued the treatment for 1 year with a maximum response of 70% decrease in mass. Disease remained stable 6 months after stopping therapy, the latest time of follow-up. Sirolimus appears to be effective in lymphangioma but requires further study.
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Supelco
Propranolol hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®
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Supelco
Propranolol hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material
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Propranolol hydrochloride, European Pharmacopoeia (EP) Reference Standard
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