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1093001

USP

Carbamazepine

United States Pharmacopeia (USP) Reference Standard

Synonyme(s) :

5H-Dibenz[b,f]azepine-5-carboxamide

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About This Item

Formule empirique (notation de Hill):
C15H12N2O
Numéro CAS:
298-46-4
Poids moléculaire :
236.27
Numéro MDL:
MFCD00005073
Code UNSPSC :
41116107
ID de substance PubChem :
329749228
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

carbamazepine

Fabricant/nom de marque

USP

Pf

191-192 °C (lit.)

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

NC(=O)N1c2ccccc2C=Cc3ccccc13

InChI

1S/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18)

Clé InChI

FFGPTBGBLSHEPO-UHFFFAOYSA-N

Informations sur le gène

human ... SCN10A(6336) , SCN11A(11280) , SCN1A(6323) , SCN2A(6326) , SCN3A(6328) , SCN4A(6329) , SCN5A(6331) , SCN7A(6332) , SCN8A(6334) , SCN9A(6335)

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Carbamazepine USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:
  • Carbamazepine Extended-Release Tablets
  • Carbamazepine Oral Suspension
  • Carbamazepine Tablets
  • Oxcarbazepine
  • Oxcarbazepine Oral Suspension
  • Oxcarbazepine Tablets

Actions biochimiques/physiologiques

Anticonvulsant; ligand for the GABAA receptor benzodiazepine modulatory site. Sodium channel inhibitor.

Remarque sur l'analyse

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Y0000033

Carbamazepine impurity A, European Pharmacopoeia (EP) Reference Standard

PHR1197

Iminostilbene, Pharmaceutical Secondary Standard; Certified Reference Material

C0450000

Carbamazepine, European Pharmacopoeia (EP) Reference Standard

1093023

Carbamazepine Related Compound B, United States Pharmacopeia (USP) Reference Standard

1093012

Carbamazepine Related Compound A, United States Pharmacopeia (USP) Reference Standard

1424084

9-Methylacridine, United States Pharmacopeia (USP) Reference Standard

BP974

Carbamazepine, British Pharmacopoeia (BP) Reference Standard

PHR1918

Carbamazepine Related Compound A, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2433

Carbamazepine Impurity F, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2330

Carbamazepine Impurity C, Pharmaceutical Secondary Standard; Certified Reference Material

PHR2237

Carbamazepine Impurity B, pharmaceutical secondary standard, certified reference material

Pictogrammes

Health hazardExclamation mark
GHS08,GHS07

Mention d'avertissement

Danger

Mentions de danger

H302,H317,H334,H336,H360FD

Classification des risques

Acute Tox. 4 Oral - Repr. 1A - Resp. Sens. 1 - Skin Sens. 1A - STOT SE 3

Organes cibles

Central nervous system

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Anna Jurado et al.
Chemosphere, 115, 47-53 (2014-02-25)
This paper deals with urban groundwater contaminated with carbamazepine (CBZ) and five of its human metabolites in Barcelona. Groundwater samples were accordingly collected in the aquifers of Poble Sec and Besòs River Delta. Higher concentrations and more compounds were found
Philip J Wiffen et al.
The Cochrane database of systematic reviews, (1)(1), CD005451-CD005451 (2011-01-21)
Carbamazepine is used to treat chronic neuropathic pain. Evaluation of analgesic efficacy and adverse effects of carbamazepine for acute and chronic pain management (except headaches). Randomised controlled trials (RCTs) of carbamazepine in acute, chronic or cancer pain were identified, searching
Wimonchat Tangamornsuksan et al.
JAMA dermatology, 149(9), 1025-1032 (2013-07-26)
The US Food and Drug Administration recommends screening for the HLA-B*1502 allele before initiation of carbamazepine therapy in patients of Asian ancestry, but there remains unclear evidence of a relationship between HLA-B*1502 and Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis
Ursula Amstutz et al.
Epilepsia, 55(4), 496-506 (2014-03-07)
To systematically review evidence on genetic risk factors for carbamazepine (CBZ)-induced hypersensitivity reactions (HSRs) and provide practice recommendations addressing the key questions: (1) Should genetic testing for HLA-B*15:02 and HLA-A*31:01 be performed in patients with an indication for CBZ therapy
Sandeep Grover et al.
Pharmacogenetics and genomics, 24(2), 94-112 (2013-12-18)
A considerable heterogeneity exists in the literature on the role of different HLA alleles in carbamazepine (CBZ)-induced cutaneous adverse drug reactions (cADRs) of varying severity among diverse ethnic groups. The aim of the present study was to understand and summarize
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