SRP3066
IGF-Binding Protein 7 human
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)
Synonyme(s) :
PGI2-stimulating factor, PSF, Prostacyclin-stimulating factor, Tumor-derived adhesion factor (TAF), IBP-7, IGF binding protein related protein-1 (IGFBPrP1), Mac25
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About This Item
Code UNSPSC :
51111800
Nomenclature NACRES :
NA.32
Produits recommandés
Source biologique
human
Produit recombinant
expressed in E. coli
Pureté
≥98% (HPLC)
≥98% (SDS-PAGE)
Forme
lyophilized
Poids mol.
26.4 kDa
Conditionnement
pkg of 25 μg
Impuretés
<0.1 EU/μg endotoxin, tested
Couleur
white to off-white
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Informations sur le gène
human ... IGFBP7(3490)
Description générale
IGFBP7 (insulin-like growth factor-binding protein 7) is from the IGFBP superfamily and is widely expressed in tissues. It contains 11 cysteines, a heparin-binding site, a Kazal-type trypsin inhibitor domain and a carboxyl-terminal immunoglobulin-like type C repeat. The IGFBP7 gene is mapped to human chromosome 4q12.
Actions biochimiques/physiologiques
IGFBP7 (insulin-like growth factor-binding protein 7) works as a tumor suppressor as well as an oncogene by controlling cell proliferation, cell attachment, apoptosis and angiogenesis. It is also involved in TGFβ (transforming growth factor β) signal pathway. IGFBP7 also interferes with the insulin pathway and is associated with the development of diabetes as well as cardiovascular diseases.IGFBP7 binds weakly to IGFs (insulin like growth factors) and strongly to insulin. It mainly participates in IGF-independent pathways.
Séquence
MSSSDTCGPC EPASCPPLPP LGCLLGETRD ACGCCPMCAR GEGEPCGGGG AGRGYCAPGM ECVKSRKRRK GKAGAAAGGP GVSGVCVCKS RYPVCGSDGT TYPSGCQLRA ASQRAESRGE KAITQVSKGT CEQGPSIVTP PKDIWNVTGA QVYLSCEVIG IPTPVLIWNK VKRGHYGVQR TELLPGDRDN LAIQTRGGPE KHEVTGWVLV SPLSKEDAGE YECHASNSQG QASASAKITV VDALHEIPVK KGEGAEL
Forme physique
Lyophilized from 10 mM Sodium Phosphate, pH 6.8.
Reconstitution
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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K L Haugk et al.
Endocrinology, 141(1), 100-110 (1999-12-30)
Skeletal myogenic cells respond to the insulin-like growth factors (IGF-I and IGF-II) by differentiating or proliferating, which are mutually exclusive pathways. What determines which of these responses to IGF skeletal myoblast undergo is unclear. IGF-binding protein-related protein 1 (IGFBP-rP1) is
Cynthia C Sprenger et al.
Oncogene, 21(1), 140-147 (2002-01-16)
In the present study, we examined the effects of over-expression of the potential tumor suppressor gene IGFBP-rP1/mac25 on cell-cycle kinetics in prostate cancer cells. The majority of the high expressing IGFBP-rP1/mac25 cell population was located in the G1 and sub-G0/G1
Heather-Marie P Wilson et al.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, 13(5), 205-213 (2002-06-18)
Elevated insulin-like growth factor binding protein-related protein 1 (IGFBP-rP1) mRNA in senescent human mammary epithelial cells suggested that the IGFBP-3 gene product may inhibit cell proliferation. To test this hypothesis, we used a retroviral vector to express IGFBP-rP1 cDNA in
Overexpressed Skp2 within 5p amplification detected by array-based comparative genomic hybridization is associated with poor prognosis of glioblastomas.
Saigusa K, et al.
Cancer Science, 96, 676-676 (2005)
Li-Hsuen Chen et al.
Journal of experimental & clinical cancer research : CR, 34, 20-20 (2015-04-17)
Aberrant insulin-like growth factor-binding protein 7 (IGFBP-7) expression has been found in various cancers such as prostate, breast, and colon. IGFBP-7 induced the apoptosis of tumor and potentially predicted the clinical outcome in some cancers is further demonstrated. This study
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