SAB5700388

Anti-Phospho-HER2/ERBB2-Y1221/1222 antibody produced in rabbit

• Synonyme(s) : CD340, ERBB2, ErbB2, HER-2, HER-2/neu, HER2, HER2/ErbB2, MLN 19, MLN19, NEU, NGL, TKR1, erb-b2 receptor tyrosine kinase 2
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.43

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: 134; 136; 137; 62; 70; 97
• Espèces réactives: human
• Concentration: 5.8 mg/ml
• Technique(s): western blot: 1:500-1:1000
• Numéro d'accès UniProt: P04626
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: phosphorylation (pTyr1221/pTyr1222)
• Informations sur le gène: human ... ERBB2(2064)

Description

Description générale

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Immunogène

A synthetic phosphorylated peptide around Y1221 & Y1222 of human HER2/ERBB2 (NP_004439.2).

Forme physique

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Stockage et stabilité

Store at -20℃. Avoid freeze / thaw cycles.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable