SAB4700088
Monoclonal Anti-CD8-PE antibody produced in mouse
clone MEM-31, purified immunoglobulin, buffered aqueous solution
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About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.44
Produits recommandés
Source biologique
mouse
Conjugué
phycoerythrin (R-PE) conjugate
Forme d'anticorps
purified immunoglobulin
Type de produit anticorps
primary antibodies
Clone
MEM-31, monoclonal
Forme
buffered aqueous solution
Espèces réactives
human
Technique(s)
flow cytometry: suitable
Isotype
IgG2a
Numéro d'accès NCBI
Conditions d'expédition
wet ice
Température de stockage
2-8°C
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... CD8(925)
Description générale
CD8 (cluster of differentiation 8), is a dimeric protein, encoded by the CD8A gene mapped to human chromosome 2p12. Human soluble CD8 (sCD8) is produced by activated CD8+ T lymphocytes.
Immunogène
Crude thymus membrane fraction
Application
The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests.
Actions biochimiques/physiologiques
CD8 (cluster of differentiation 8) acts as a vital co-receptor of cytotoxic T cells. Mutation in the gene has been associated with the development of respiratory infections. Soluble CD8 plays a major role in regulation of soluble human leucocyte antigen I (sHLA-I) mediated transfusion-related immunomodulation (TRIM). Elevated levels of sCD8 has been observed in polytransfused patients suffering from human immunodeficiency virus-negative haemophilia and β-thalassaemia major.
Caractéristiques et avantages
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Forme physique
Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Blood transfusions with high levels of contaminating soluble HLA-I correlate with levels of soluble CD8 in recipients' plasma; a new control factor in soluble HLA-I-mediated transfusion-modulated immunomodulation?
Ghio M
Blood Transfusion = Trasfusione del Sangue, s105-s108 (2014)
An RFLP associated with pcDLeu2-14, a human T-cell differentiation antigen CD8 (Leu2) cDNA mapped to 2p12.
Bowcock AM
Nucleic Acids Research, 14 (1986)
Recurrent Respiratory Infections Revealing CD8? Deficiency.
Dumontet E
Journal of clinical immunology, 35, 692-695 (2015)
Eun-Mi Kim et al.
Immunology, 142(3), 421-430 (2014-02-18)
Murine embryonic stem (ES) cell-derived haematopoietic progenitor cells (HPCs) engraft and populate lymphoid organs. In vivo, HPCs engraft across MHC barriers protecting donor-type allografts from rejection. However, the underlying phenomenon remains elusive. Here, we sought to determine the mechanism by
Madonna R Peter et al.
Mediators of inflammation, 2014, 767185-767185 (2014-08-13)
Endoglin is a coreceptor of the TGF-β superfamily predominantly expressed on the vascular endothelium and selective subsets of immune cells. We previously demonstrated that Endoglin heterozygous (Eng (+/-)) mice subjected to dextran sulfate sodium (DSS) developed persistent gut inflammation and
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