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SAB4500379

Sigma-Aldrich

Anti-TSH2 antibody produced in rabbit

affinity isolated antibody

Synonyme(s) :

OVC10-2, Ovarian cancer-related protein 10-2, Zinc finger protein 218

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

antigen 115 kDa

Espèces réactives

human, mouse

Concentration

~1 mg/mL

Technique(s)

ELISA: 1:20000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100

Numéro d'accès NCBI

Q9NRE2

Numéro d'accès UniProt

Q9NRE2

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... TSHZ2(128553)

Description générale

Anti-TSH2 Antibody detects endogenous levels of total TSH2 protein.
TSH2/TSHZ2 (teashirt zinc finger homeobox 2) is a nuclear protein. It has four zinc-finger (ZF) domains, a homeobox domain and a coiled-coil domain. It is located on human chromosome 20q13.2.

Immunogène

The antiserum was produced against synthesized peptide derived from human TSH2.

Immunogen Range: 811-860

Actions biochimiques/physiologiques

TSH2/TSHZ2 (teashirt zinc finger homeobox 2) acts as a C-terminal binding protein (CtBP)-dependent transcriptional repressor. At the time of mammary tumorigenesis, low level expression of TSH2 liberates GLI1 (glioma-associated oncogene homolog 1) from the nuclear repressor complex to update its transcriptional activity.

Caractéristiques et avantages

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forme physique

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Lessons learned from the initial sequencing of the pig genome: comparative analysis of an 8 Mb region of pig chromosome 17
Hart EA, et al.
Genome Biology (2007)
Down-regulation of the zinc-finger homeobox protein TSHZ2 releases GLI1 from the nuclear repressor complex to restore its transcriptional activity during mammary tumorigenesis
Miho Riku
Oncotarget, 7(5), 5690-5701 (2016)
Madeline A Lancaster et al.
Nature, 501(7467), 373-379 (2013-09-03)
The complexity of the human brain has made it difficult to study many brain disorders in model organisms, highlighting the need for an in vitro model of human brain development. Here we have developed a human pluripotent stem cell-derived three-dimensional

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

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