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Q1250

Sigma-Aldrich

Quinine hemisulfate salt monohydrate

synthetic, ≥90% (HPLC)

Synonyme(s) :

Quinine sulfate (2:1) (salt) dihydrate

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About This Item

Formule empirique (notation de Hill):
C20H24N2O2 · 0.5H2O4S · H2O
Numéro CAS:
207671-44-1
Poids moléculaire :
391.47
Numéro Beilstein :
6113937
Numéro MDL:
MFCD00150790
Code UNSPSC :
12352210
ID de substance PubChem :
57654578
Nomenclature NACRES :
NA.77

Source biologique

synthetic

Pureté

≥90% (HPLC)

Pf

~225 °C (dec.) (lit.)

Solubilité

H2O: slightly soluble 1.2 mg/mL
ethanol: 8 mg/mL

Spectre d'activité de l'antibiotique

parasites

Mode d’action

enzyme | inhibits

Auteur

Bayer

Chaîne SMILES 

O.O.OS(O)(=O)=O.COc1ccc2nccc([C@@H](O)C3CC4CCN3C[C@@H]4C=C)c2c1.COc5ccc6nccc([C@@H](O)C7CC8CCN7C[C@@H]8C=C)c6c5

InChI

1S/2C20H24N2O2.H2O4S.2H2O/c2*1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18;1-5(2,3)4;;/h2*3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3;(H2,1,2,3,4);2*1H2/t2*13-,14-,19-,20+;;;/m00.../s1

Clé InChI

ZHNFLHYOFXQIOW-LPYZJUEESA-N

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Application

Quinine hemisulfate salt monohydrate has been used as a stimuli to evaluate its influence on sensory and cognitive factors.

Actions biochimiques/physiologiques

Potassium channel blocker. Antimalarial, anticholinergic, antihypertensive, and hypoglycemic agent; alkaloid originally isolated from the Cinchona family of South American trees. Inhibits mitochondrial ATP-regulated potassium channel. Used to study the metabolism of biocrystalized heme, hemozoin, in malarial parasites and to study the toxicity of heme (FP)-complexes.
Quinine has analgesic property.

Caractéristiques et avantages

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H315,H319,H335

Classification des risques

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

F A Santos et al.
European journal of pharmacology, 364(2-3), 193-197 (1999-02-05)
The effect of quinine, a cinchona alkaloid, was studied on gastrointestinal transit in mice. Intraperitoneal (i.p.) administration of quinine inhibited the intestinal propulsion of a charcoal suspension at a dose of 100 mg/kg, comparing favorably with 5 mg/kg morphine. In
Elizabeth A Sneddon et al.
Alcoholism, clinical and experimental research, 43(2), 243-249 (2018-11-16)
Alcohol use disorder is characterized by compulsive alcohol intake, or drinking despite negative consequences. Previous studies have shown that female rodents have a heightened vulnerability to drug use across different stages of the addictive cycle, but no previous studies have
Both perceptual and conceptual factors influence taste-odor and taste-taste interactions
Frank RA, et al.
Perception & Psychophysics, 54(3), 343-354 (1993)
E M Clement et al.
Neuropharmacology, 37(7), 945-951 (1998-10-17)
Quinine and quinidine are reported to potentiate the behavioural effects of serotonergic agents and monoamine uptake inhibitors. We have therefore investigated the presynaptic actions of quinine and quinidine on monoamine uptake and release in rat brain tissue in vitro. Quinidine
A Hedman et al.
Journal of pharmaceutical sciences, 87(4), 457-461 (1998-04-21)
The pharmacokinetic interaction between quinidine and digoxin in patients is well-known, in general requiring a dose reduction of digoxin in patients concomitantly treated with quinidine. Quinine, the diastereomer of quinidine, has not been as extensively studied in this respect. In
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