H0915

Hydroxychloroquine sulfate

≥98% (HPLC), powder, anti-inflammatory

• Synonyme(s) : Hydroxychloroquine sulfate, 7-Chloro-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinoline sulfate
• Formule empirique (notation de Hill): C₁₈H₂₆ClN₃O · H₂SO₄
• Numéro CAS: 747-36-4
• Poids moléculaire : 433.95
• Numéro CE : 212-019-3
• Numéro MDL: MFCD00078203
• Code UNSPSC : 12352200
• ID de substance PubChem : 329815141
• Nomenclature NACRES : NA.77

Propriétés

• product name: Hydroxychloroquine sulfate, ≥98% (HPLC), powder
• Pureté: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: protect from light
• Couleur: white to off-white
• Solubilité: H₂O: >20 mg/mL
• Chaîne SMILES: OS(O)(=O)=O.CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12
• InChI: 1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18;1-5(2,3)4/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);(H2,1,2,3,4)
• Clé InChI: JCBIVZZPXRZKTI-UHFFFAOYSA-N
• Informations sur le gène: human ... TLR7(51284) , TLR9(54106)

Description

Application

Hydroxychloroquine sulfate has been used:

• as an inhibitor of autophagy to treat cells for apoptosis assay to study the role of pirarubicin induced autophagy in bladder cancer cell line
• to evaluate the antiviral mechanism of hydroxychloroquine against DENV-2 (dengue virus-2) infection by immunofluorescence assay
• to inhibit lysosome fusion with the autophagosome

Actions biochimiques/physiologiques

Hydroxychloroquine is also used for treating rheumatoid arthritis and systemic lupus erythematosus.

Hydroxychloroquine sulfate is an anti-inflammatory (via TNF), disease-modifying antirheumatic drug (DMARD), and a heme polymerase inhibitor. It is used in treating malaria.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H315,H319
• Conseils de prudence: P264 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338 - P332 + P313
• Classification des risques: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves