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Documents

Y0000588

Venlafaxine hydrochloride

Name: Venlafaxine hydrochloride
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

(+/-)-1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride, Effexor

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About This Item

Formule empirique (notation de Hill):

C₁₇H₂₇NO₂ · HCl

Numéro CAS:

99300-78-4

Poids moléculaire :

313.86

Numéro MDL:

MFCD03658865

Code UNSPSC :

41116107

ID de substance PubChem :

329831037

Nomenclature NACRES :

NA.24

Qualité

pharmaceutical primary standard

Famille d'API

venlafaxine

Fabricant/nom de marque

EDQM

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES

Cl[H].COc1ccc(cc1)C(CN(C)C)C2(O)CCCCC2

InChI

1S/C17H27NO2.ClH/c1-18(2)13-16(17(19)11-5-4-6-12-17)14-7-9-15(20-3)10-8-14;/h7-10,16,19H,4-6,11-13H2,1-3H3;1H

Clé InChI

QYRYFNHXARDNFZ-UHFFFAOYSA-N

Informations sur le gène

human ... SLC6A2(6530) , SLC6A4(6532)

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Catégories apparentées

Étalons des instituts de métrologie et des pharmacopées

Matériaux de référence analytiques pour l'industrie pharmaceutique

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Venlafaxine for system suitability EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Actions biochimiques/physiologiques

Venlafaxine is an antidepressant. The mechanism of the antidepresant action of venlafaxine in humans is associated with its potentiation of neurotransmitter activity in the CNS. Venlafaxine is a potent inhibitor of neuronal serotonin and norepinephrine reuptake and weak inhibitor of dopamine reuptake. Venlafaxine has no significant activity for muscarinic, histaminergic, or α-1 adrenergic receptors in vitro. Venlafaxine does not possess MAO inhibitor activity.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Classification des risques

Aquatic Chronic 2

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number

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The spectrum of acute heart failure after venlafaxine overdose.

M Batista et al.

Clinical toxicology (Philadelphia, Pa.), 51(2), 92-95 (2013-01-11)

Venlafaxine is a bicyclic antidepressant that may be associated with severe cardiotoxicity following large overdose. The purpose of this short case series is to present different patterns of venlafaxine-related cardiotoxicity and to discuss the potential mechanisms. Between January 2010 and

Randomized trial to assess the impact of venlafaxine and soy protein on hot flashes and quality of life in men with prostate cancer.

Mara Z Vitolins et al.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(32), 4092-4098 (2013-10-02)

Hot flashes occur in approximately 80% of androgen-deprived men. Few intervention studies have been conducted to relieve hot flashes in men. Eligible androgen-deprived men were randomly assigned to one of four daily regimens (2 × 2 factorial design) for 12

Relationships between changes in sustained fronto-striatal connectivity and positive affect in major depression resulting from antidepressant treatment.

Aaron S Heller et al.

The American journal of psychiatry, 170(2), 197-206 (2012-12-12)

OBJECTIVE Deficits in positive affect and their neural bases have been associated with major depression. However, whether reductions in positive affect result solely from an overall reduction in nucleus accumbens activity and fronto-striatal connectivity or the additional inability to sustain

Association between reported venlafaxine use in early pregnancy and birth defects, national birth defects prevention study, 1997-2007.

Kara N D Polen et al.

Birth defects research. Part A, Clinical and molecular teratology, 97(1), 28-35 (2013-01-03)

Few epidemiologic studies have investigated the use of venlafaxine (Effexor XR capsules, Product Monograph, Wyeth, Montreal, Canada), an antidepressant used to treat major depression and anxiety disorders in adults, during pregnancy. Our objective was to determine whether use of venlafaxine

Treating wastewater from a pharmaceutical formulation facility by biological process and ozone.

Yaal Lester et al.

Water research, 47(13), 4349-4356 (2013-06-15)

Wastewater from a pharmaceutical formulation facility (TevaKS, Israel) was treated with a biological activated-sludge system followed by ozonation. The goal was to reduce the concentrations of the drugs carbamazepine (CBZ) and venlafaxine (VLX) before discharging the wastewater to the municipal

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