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P2700000

Prednisolone

Name: Prednisolone
Brand: SIAL

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

1,4-pregnadiène-11β,17α,21-triol-3,20-dione, 11β,17α,21-trihydroxy-1,4-pregnadiène-3,20-dione

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About This Item

Formule empirique (notation de Hill):

C₂₁H₂₈O₅

Numéro CAS:

50-24-8

Poids moléculaire :

360.44

Numéro Beilstein :

1354103

Numéro MDL:

MFCD00003649

Code UNSPSC :

41116107

ID de substance PubChem :

329820150

Nomenclature NACRES :

NA.24

Qualité

pharmaceutical primary standard

Famille d'API

prednisolone

Fabricant/nom de marque

EDQM

Pf

240 °C (dec.) (lit.)

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES

O=C1C=C[C@@]2(C)C(CC[C@]3([H])[C@]2([H])[C@@H](O)C[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(CO)=O)=C1

InChI

1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h5,7,9,14-16,18,22,24,26H,3-4,6,8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

Clé InChI

OIGNJSKKLXVSLS-VWUMJDOOSA-N

Informations sur le gène

human ... NR3C1(2908)

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Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Prednisolone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit

Description

Tarif

Mention d'avertissement

Danger

Mentions de danger

H360FD

Conseils de prudence

P201 - P202 - P280 - P308 + P313 - P405 - P501

Classification des risques

Repr. 1B

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 2

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Certificats d'analyse (COA)

Lot/Batch Number

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A case of toxic epidermal necrolysis with diverse etiologies: successful treatment with intravenous immunoglobulin and pulse prednisolone and effects on sTRAIL and sCD200 levels.

Arzu Didem Yalcin et al.

Clinical laboratory, 59(5-6), 681-685 (2013-07-20)

Here, we report the first case of patient with intracranial tumors (ICT) who developed a cutaneous adverse drug reaction during lansoprazole and prophylactic anticonvulsant treatment. SCORTEN is a scoring system used to predict mortality in TEN patients. If SCORTEN index

Targeted treatment with a combination of traditional DMARDs produces excellent clinical and radiographic long-term outcomes in early rheumatoid arthritis regardless of initial infliximab. The 5-year follow-up results of a randomised clinical trial, the NEO-RACo trial.

Vappu Rantalaiho et al.

Annals of the rheumatic diseases, 73(11), 1954-1961 (2013-08-03)

To study whether adding initial infliximab to remission-targeted initial combination-DMARD treatment improves the long-term outcomes in patients with early rheumatoid arthritis (RA). Ninety-nine patients with early, DMARD-naïve RA were treated with a triple combination of DMARDs, starting with methotrexate (max

Chemical genomic screening identifies LY294002 as a modulator of glucocorticoid resistance in MLL-rearranged infant ALL.

J A P Spijkers-Hagelstein et al.

Leukemia, 28(4), 761-769 (2013-08-21)

Successful treatment results for MLL-rearranged Acute Lymphoblastic Leukemia (ALL) in infants remain difficult to achieve. Significantly contributing to therapy failure is poor response to glucocorticoids (GCs), like prednisone. Thus, overcoming resistance to these drugs may be a crucial step towards

Safety of cabazitaxel in senior adults with metastatic castration-resistant prostate cancer: results of the European compassionate-use programme.

Axel Heidenreich et al.

European journal of cancer (Oxford, England : 1990), 50(6), 1090-1099 (2014-02-04)

Cabazitaxel/prednisone has been shown to prolong survival versus mitoxantrone/prednisone in patients with metastatic castration-resistant prostate cancer (mCRPC) that has progressed during or after docetaxel. Subsequently, compassionate-use programmes (CUPs) and expanded-access programmes (EAPs) were established worldwide, allowing access to cabazitaxel before

Hemostatic effect of hot saline irrigation during functional endoscopic sinus surgery: a randomized controlled trial.

Eng Cern Gan et al.

International forum of allergy & rhinology, 4(11), 877-884 (2014-08-20)

The endoscopically magnified operative field in functional endoscopic sinus surgery (FESS) makes even a small amount of bleeding a potentially significant hindrance. It is thought that irrigation with hot saline during surgery may improve surgical field of view by producing

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Protocoles

HPLC Analysis of Prednisolone (Secondary Pharma Standard) on Ascentis® C18

Separation of Prednisolone, pharmaceutical secondary standard; traceable to USP, PhEur and BP

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