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Dansyl chloride

for HPLC derivatization, LiChropur™, ≥99.0% (HPLC)

Synonyme(s) :

5-(Dimethylamino)naphthalene-1-sulfonyl chloride, DNSCl

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About This Item

Formule empirique (notation de Hill):
C12H12ClNO2S
Numéro CAS:
605-65-2
Poids moléculaire :
269.75
Numéro Beilstein :
2217205
Numéro CE :
210-092-6
Numéro MDL:
MFCD00003985
Code UNSPSC :
41116105
ID de substance PubChem :
329747747
Nomenclature NACRES :
NA.22

Qualité

for HPLC derivatization
LiChropur™

Niveau de qualité

100

Pureté

≥99.0% (HPLC)

Forme

powder or crystals

Technique(s)

HPLC: suitable

Pf

72-74 °C (lit.)

Solubilité

acetone: 0.2 g/10 mL, clear to slightly turbid, yellow to very dark yellow-orange

Température de stockage

2-8°C

Chaîne SMILES 

CN(C)c1cccc2c(cccc12)S(Cl)(=O)=O

InChI

1S/C12H12ClNO2S/c1-14(2)11-7-3-6-10-9(11)5-4-8-12(10)17(13,15)16/h3-8H,1-2H3

Clé InChI

XPDXVDYUQZHFPV-UHFFFAOYSA-N

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Description générale

Dansyl chloride is a fluorogenic reagent which is typically employed for the derivatization of amino acids.

Application

Dansyl chloride has been used for the fluorogenic labeling of xenoestrogens, 4-nonylphenol and bisphenol A prior to their determination by high-performance liquid chromatography (HPLC) with fluorescence detection. It has also been used for the derivatization of icariin in human serum samples after oral administration of Epimedium decoction, followed by its determination using ultrasensitive LC-tandem mass spectrometry (LC-MS) and for the derivatization of antitumoral agent ES-285 in dog plasma followed by its analysis by HPLC equipped with ultraviolet and fluorescence detection.
A fluorogenic reagent for fluorescent N-terminal derivatization of amino acids and peptides and detection by reverse phase HPLC.

Produits recommandés

Discover LiChropur reagents ideal for HPLC or LC-MS analysis

Informations légales

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Pictogrammes

Corrosion
GHS05

Mention d'avertissement

Danger

Mentions de danger

H290,H314

Classification des risques

Eye Dam. 1 - Met. Corr. 1 - Skin Corr. 1B

Code de la classe de stockage

8A - Combustible corrosive hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

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Certificats d'analyse (COA)

Lot/Batch Number
BCCF7035
BCCF4235
BCCD5666
BCCD5096
BCCD1095

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Phenylisothiocyanate and dansyl chloride precolumn derivatizations for the high-performance liquid chromatography analysis of the antitumoral agent ES-285 in dog plasma.
Maraschiello, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 791(1-2), 1-11 (2003)
Trace analysis of icariin in human serum with dansyl chloride derivatization after oral administration of Epimedium decoction by liquid chromatography tandem mass spectrometry.
Gong, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 860(2), 166-172 (2007)
Determination of the xenoestrogens 4-nonylphenol and bisphenol A by high-performance liquid chromatography and fluorescence detection after derivatisation with dansyl chloride.
Naassner, et al.
Journal of Chromatography A, 945(1-2), 133-138 (2002)
Tomofumi Santa
Biomedical chromatography : BMC, 25(1-2), 1-10 (2010-11-09)
Liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS) is one of the most prominent analytical techniques owing to its inherent selectivity and sensitivity. In LC/ESI-MS/MS, chemical derivatization is often used to enhance the detection sensitivity. Derivatization improves the chromatographic separation, and
Miguel López-Gómez et al.
Phytochemistry, 107, 32-41 (2014-09-16)
Polyamines (PAs) are low molecular weight aliphatic compounds that have been shown to be an important part of plant responses to salt stress. For that reason in this work we have investigated the involvement of PAs in the response to
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