527451

PKR Inhibitor

InSolution, ≥90%

• Synonyme(s) : InSolution PKR Inhibitor, Double-stranded RNA-activated Protein Kinase Inhibitor I, Double-stranded RNA-dependent Protein Kinase Inhibitor I, EIF2AK2 Inhibitor I, C16
• Formule empirique (notation de Hill): C₁₃H₈N₄OS
• Numéro CAS: 608512-97-6
• Poids moléculaire : 268.29
• Numéro MDL: MFCD06735404
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Pureté: ≥90% (HPLC)
• Forme: liquid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; avoid repeated freeze/thaw cycles; desiccated (hygroscopic); protect from light
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• InChI: 1S/C13H8N4OS/c18-13-8(3-7-4-14-5-15-7)11-9(17-13)1-2-10-12(11)19-6-16-10/h1-6H,(H,14,15)(H,17,18)/b8-3-
• Clé InChI: VFBGXTUGODTSPK-BAQGIRSFSA-N

Description

Description générale

An imidazolo-oxindole compound that acts as a potent, ATP-binding site directed inhibitor of PKR. Shown to effectively inhibit RNA-induced PKR autophosphorylation (IC₅₀ = 210 nM) and rescue PKR-dependent translation block (IC₅₀ = 100 nM). The solid form of this compound (Cat. No. 527450) is also available.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
PKR

Reversible: yes

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Irritant (B)

Forme physique

A 50 mM (5 mg/373 µL) solution of PKR Inhibitor (Cat. No. 527450) in DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.

Autres remarques

Zhu, P.J., et al. 2011. Cell147, 1384.
Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun.308, 50.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany