422500

Kifunensine, Kitasatosporia kifunense

A potent alkaloid inhibitor of mannosidase I.

• Synonyme(s) : Kifunensine, Kitasatosporia kifunense
• Formule empirique (notation de Hill): C₈H₁₂N₂O₆
• Numéro CAS: 109944-15-2
• Poids moléculaire : 232.19
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (TLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; desiccated (hygroscopic)
• Couleur: white
• Solubilité: hot water: 25 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• InChI: 1S/C8H12N2O6/c11-1-2-3(12)4(13)5(14)6-9-7(15)8(16)10(2)6/h2-6,11-14H,1H2,(H,9,15)/t2-,3-,4+,5+,6+/m1/s1
• Clé InChI: OIURYJWYVIAOCW-PQMKYFCFSA-N

Description

Description générale

A potent alkaloid inhibitor of mannosidase I. An ineffective inhibitor of mannosidase II and the endoplasmic reticulum α-mannosidase.

A potent alkaloid inhibitor of mannosidase I. Does not affect mannosidase II and the endoplasmic reticulum α-mannosidase.

Actions biochimiques/physiologiques

Cell permeable: no

Primary Target
mannosidase-1

Product does not compete with ATP.

Reversible: no

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Weng, S., and Spiro, R.G. 1996. Arch. Biochem. Biophys.325, 113.
Kayakiri, H., et al. 1991. Chem. Pharm. Bull. 39, 1378.
Elbein, A.D., et al. 1990. J. Biol. Chem. 265, 15599.
Iwami, M., et al. 1987. J. Antibiotic. 40, 612.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H319
• Conseils de prudence: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Classification des risques: Eye Irrit. 2
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable