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Documents

C66056

4-(4-Chlorophenyl)-4-hydroxypiperidine

Name: 4-(4-Chlorophenyl)-4-hydroxypiperidine
Brand: ALDRICH

99%

Synonyme(s) :

Haloperidol metabolite I, 4-(4-Chlorophenyl)-4-hydroxypiperidine, 4-(4-Chlorophenyl)-4-piperidinol

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About This Item

Formule empirique (notation de Hill):

C₁₁H₁₄ClNO

Numéro CAS:

39512-49-7

Poids moléculaire :

211.69

Numéro CE :

254-479-8

Numéro MDL:

MFCD00006001

Code UNSPSC :

12352100

ID de substance PubChem :

24892880

Nomenclature NACRES :

NA.22

Pureté

99%

Forme

powder

Pf

137-140 °C (lit.)

Chaîne SMILES

OC1(CCNCC1)c2ccc(Cl)cc2

InChI

1S/C11H14ClNO/c12-10-3-1-9(2-4-10)11(14)5-7-13-8-6-11/h1-4,13-14H,5-8H2

Clé InChI

LZAYOZUFUAMFLD-UHFFFAOYSA-N

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Pictogrammes

GHS05,GHS07

Mention d'avertissement

Danger

Mentions de danger

H302,H315,H317,H318,H412

Conseils de prudence

P261 - P273 - P280 - P301 + P312 - P302 + P352 - P305 + P351 + P338

Classification des risques

Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

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Consulter la Bibliothèque de documents

[Chemical toxicological analysis of haloperidol metabolite 4-(4-chlorophenyl)-4-hydroxypipiridine in urine by high-performance liquid chromatography].

A B Skorniakova et al.

Sudebno-meditsinskaia ekspertiza, 52(1), 45-48 (2009-04-18)

Haloperidol is extensively used in current psychiatric practice for the treatment of various psychotic disorders. However, this substance is known to be toxic and sometimes cause poisoning despite its generally positive therapeutic effect. Moreover, some of its metabolites also possess

Sensitive determination of 4-(4-chlorophenyl)-4-hydroxypiperidine, a metabolite of haloperidol, in a rat biological sample by HPLC with fluorescence detection after pre-column derivatization using 4-fluoro-7-nitro-2,1,3-benzoxadiazole.

Yasuhiko Higashi et al.

Biomedical chromatography : BMC, 20(9), 964-970 (2006-03-01)

4-(4-Chlorophenyl)-4-hydroxypiperidine (CPHP), one of the metabolites of haloperidol, is considered to exhibit brain toxicity. CPHP concentrations in plasma and tissue homogenates (each 200 microL) from rats were analyzed by HPLC fluorescence detection after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F). After basic

Salt formation in solid dispersions consisting of polyacrylic acid as a carrier and three basic model compounds resulting in very high glass transition temperatures and constant dissolution properties upon storage.

Ilse Weuts et al.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 25(4-5), 387-393 (2005-05-17)

The purpose of the study was to investigate the suitability of polyacrylic acid (PAA) as a carrier in solid dispersions, with the aim to delay crystallization of basic drugs and improve their dissolution behaviour. The physicochemical properties were investigated in

Determination of 4-(4-chlorophenyl)-4-hydroxypiperidine, a metabolite of haloperidol, by gas chromatography with electron-capture detection.

J Fang et al.

Journal of chromatography. B, Biomedical applications, 682(2), 283-288 (1996-07-12)

An electron-capture gas chromatographic procedure was developed for the analysis of 4-(4-chlorophenyl)-4-hydroxypiperidine (CPHP), a metabolite of haloperidol. The assay involved basic extraction of this metabolite from the biological samples, followed by back-extraction with HCl. After basification of the acid phase

In-vitro characterization of the cytochrome P450 isoenzymes involved in the back oxidation and N-dealkylation of reduced haloperidol.

L P Pan et al.

Pharmacogenetics, 8(5), 383-389 (1998-11-24)

In-vitro studies were performed using human liver microsomes and c-DNA-expressed human P450 isoforms to identify the cytochrome P450 isoenzyme(s) involved in the back oxidation and N-dealkylation of reduced haloperidol. Back oxidation and N-dealkylation of reduced haloperidol were assessed by measuring

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