902527

Amino-PEG5-t-butyl ester

≥95%

• Synonyme(s) : tert-Butyl-1-amino-3,6,9,12,15-pentaoxaoctadecan-18-oate, H₂N-PEG₅-CH₂CH₂COOtBu
• Formule empirique (notation de Hill): C₁₇H₃₅NO₇
• Numéro CAS: 1446282-18-3
• Poids moléculaire : 365.46
• Numéro MDL: MFCD25424125
• Code UNSPSC : 51171641

Propriétés

• Pureté: ≥95%
• Forme: liquid
• Pertinence de la réaction: reagent type: cross-linking reagent
• Indice de réfraction: n/D 1.4534
• Densité: 1.4690 g/mL
• Groupe fonctionnel: amine; ester
• Température de stockage: −20°C
• Chaîne SMILES: NCCOCCOCCOCCOCCOCCC(OC(C)(C)C)=O

Description

Application

This heterobifunctional, PEGylated crosslinker features an amino group at one end and t-butyl-protected carboxyl group at the other, which can be deprotected with acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. Amino-PEG5-t-butyl ester can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

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Informations légales

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°C): No data available