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Merck

THRB

thyroid hormone receptor, beta

Synonymes:
C-ERBA-2, C-ERBA-BETA, ERBA2, GRTH, NR1A2, PRTH, THR1, THRB1, THRB2
Espèce(s):
Human THRB (7068), Mouse Thrb (21834), Rat Thrb (24831), Zebrafish thrb (30607), Horse THRB (100051615), domestic cat THRB (101084821), chicken THRB (396431), dog THRB (403599), cow THRB (788329), naked mole-rat Thrb (101719651) ...Plus
ID UniProtKB:
P10828, B3KU79, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
ID du gène:
  • Human(7068) Summary: The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]
  • Mouse(21834) thyroid hormone receptor beta
  • Rat(24831) thyroid hormone receptor beta
  • Zebrafish(30607) thyroid hormone receptor beta
  • Horse(100051615) thyroid hormone receptor, beta
  • domestic cat(101084821) thyroid hormone receptor, beta
  • chicken(396431) thyroid hormone receptor, beta
  • dog(403599) thyroid hormone receptor, beta
  • cow(788329) thyroid hormone receptor, beta
  • naked mole-rat(101719651) thyroid hormone receptor, beta
  • Domestic Rabbit(100303763) thyroid hormone receptor, beta
  • domestic guinea pig(100721125) thyroid hormone receptor, beta

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Small Molecule - Agonist

Référence du produit
Description
Espèce(s)
1365000
Levothyroxine, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
T-074
3,3′,5-Triiodo-L-thyronine (T3) solution, 100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®,
Espèce(s)
human
T-073
L-Thyroxine (T4) solution, 100 μg/mL in methanol with 0.1N NH3, ampule of 1 mL, certified reference material, Cerilliant®,
Espèce(s)
human
1368008
Liothyronine, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
1365065
Levothyroxine sodium hydrate, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human

Small Molecule - Antagonist

Référence du produit
Description
Espèce(s)
T6397
3,3′,5-Triiodo-L-thyronine sodium salt, powder, BioReagent, suitable for cell culture,
Espèce(s)
rat, human
T2877
3,3′,5-Triiodo-L-thyronine, ≥95% (HPLC), powder,
Espèce(s)
rat, human
T5516
3,3′,5-Triiodo-L-thyronine sodium salt, γ-irradiated, powder, suitable for, suitable for cell culture,
Espèce(s)
rat, human
T7650
3,3′,5-Triiodothyroacetic acid, ≥90%,
Espèce(s)
rat, human
T2376
L-Thyroxine, ≥98% (HPLC),
Espèce(s)
human, mouse, rat

Antibodies

Référence du produit
Description
Espèces réactives
Application
ABN25
Anti-Thyroid Hormone Receptor β-1 Antibody, from rabbit, purified by affinity chromatography,
Espèces réactives
human, mouse, rat
Application
western blot
SAB4502969
Anti-Thyroid Hormone Receptor β, N-Terminal antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
HPA061035
Anti-THRB antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence
SAB4504736
Anti-phospho-TR-β1 (pSer142) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
western blot
SAB2501038
Anti-THRB antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Espèces réactives
canine, human, mouse, rat
Application
ELISA
western blot

Small Molecule - Blocker

Référence du produit
Description
Espèce(s)
T6397
3,3′,5-Triiodo-L-thyronine sodium salt, powder, BioReagent, suitable for cell culture,
Espèce(s)
rat, human
T2877
3,3′,5-Triiodo-L-thyronine, ≥95% (HPLC), powder,
Espèce(s)
rat, human
T5516
3,3′,5-Triiodo-L-thyronine sodium salt, γ-irradiated, powder, suitable for, suitable for cell culture,
Espèce(s)
rat, human

esiRNA

Référence du produit
Description
Espèce(s)
EHU083461
MISSION® esiRNA, targeting human THRB,
Espèce(s)
human