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Merck

SMAD1

SMAD family member 1

Synonymes:
BSP-1, BSP1, JV4-1, JV41, MADH1, MADR1
Espèce(s):
Human SMAD1 (4086), Mouse Smad1 (17125), Rat Smad1 (25671), cow SMAD1 (540488), sheep SMAD1 (443229), domestic guinea pig Smad1 (100727257), naked mole-rat Smad1 (101725903), Domestic Rabbit SMAD1 (100341544), Zebrafish smad1 (30628), domestic cat SMAD1 (101085713) ...Plus
ID UniProtKB:
Q15797, A8KAJ0, D3DNZ9, Q16636
ID du gène:
  • Human(4086) Summary: The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
  • Mouse(17125) SMAD family member 1
  • Rat(25671) SMAD family member 1
  • cow(540488) SMAD family member 1
  • sheep(443229) SMAD family member 1
  • domestic guinea pig(100727257) SMAD family member 1
  • naked mole-rat(101725903) SMAD family member 1
  • Domestic Rabbit(100341544) SMAD family member 1
  • Zebrafish(30628) MAD homolog 1 (Drosophila)
  • domestic cat(101085713) SMAD family member 1
  • Horse(100033850) SMAD family member 1
  • dog(475456) SMAD family member 1
  • chicken(395680) SMAD family member 1

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Antibodies

Référence du produit
Description
Espèces réactives
Application
AB3848-I
Anticorps anti-phospho-Smad1/Smad5/Smad8 (Ser463/465), from rabbit, purified by affinity chromatography,
Espèces réactives
xenopus, human, mink, mouse, rat
Application
immunohistochemistry
western blot
06-702
Anticorps anti-phospho-Smad1 (Ser463/465), Upstate®, from rabbit,
Espèces réactives
xenopus, human, mouse, rat
Application
western blot
ZRB1572
Anti-pSmad1 Ser463/465 Antibody, clone 1N12 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Espèces réactives
bovine, canine, chicken, feline, horse, human, monkey, mouse, rat
Application
affinity binding assay
peptide synthesis
western blot
ABE2871
Anti-phospho-Smad1 (Ser463 Antibody, Ser465), from rabbit,
Espèces réactives
human, rat
Application
immunoprecipitation (IP)
western blot
SAB4501801
Anti-SMAD1 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot

Proteins

Référence du produit
Description
Espèce(s)
SRP5130
SMAD1, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
EHU051601
MISSION® esiRNA, targeting human SMAD1,
Espèce(s)
human