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PHR1338

Supelco

Triclosan

Pharmaceutical Secondary Standard; Certified Reference Material

Synonym(s):

Triclosan, 5-Chloro-2-(2,4-dichlorophenoxy)phenol, Irgasan

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60 ML
CA$194.00

CA$194.00

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60 ML
CA$194.00

About This Item

Empirical Formula (Hill Notation):
C12H7Cl3O2
CAS Number:
3380-34-5
Molecular Weight:
289.54
Beilstein:
2057142
EC Number:
222-182-2
MDL number:
MFCD00800992
UNSPSC Code:
41116107
PubChem Substance ID:
329823323
NACRES:
NA.24

CA$194.00

Please contact Customer Service for Availability
Request a Bulk Order

grade

certified reference material
pharmaceutical secondary standard

Quality Level

300

Agency

traceable to USP 1682206

API family

triclosan

CofA

current certificate can be downloaded

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-30°C

SMILES string

Oc1cc(Cl)ccc1Oc2ccc(Cl)cc2Cl

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934537277934228
Triclosan Pharmaceutical Secondary Standard; Certified Reference Material

PHR1338

Triclosan

Triclosan certified reference material, TraceCERT®, Manufactured by: Sigma-Aldrich Production GmbH, Switzerland

93453

Triclosan

Triclosan 97.0-103.0% (active substance, GC)

72779

Triclosan

Triclosan-methyl PESTANAL®, analytical standard

34228

Triclosan-methyl

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

format

neat

format

neat

format

-

format

neat

Quality Level

300

Quality Level

300

Quality Level

200

Quality Level

100

grade

certified reference material, pharmaceutical secondary standard

grade

certified reference material, TraceCERT®

grade

-

grade

analytical standard

storage temp.

2-30°C

storage temp.

-

storage temp.

-

storage temp.

-

General description

Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to in-house working standards.
Triclosan is a non-ionic broad spectrum antibacterial and antifungal agent, used in personal care products such as antiseptic soaps, toothpastes, fabrics and plastics.[1]

Application

A component of cefsulodin-irgasan-novobiocin selection medium for Yersinia, a human pathogen that may contaminate animal-source food products.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Triclosan may be used as a pharmaceutical reference standard for the determination of the analyte in waste water samples[2] and food stuffs[3] by various chromatography methods.

Biochem/physiol Actions

It is an inhibitor of the enoyl-ACP (acyl-carrier protein) reductase component of type II fatty acid synthase (FAS-II) in bacteria and Plasmodium. It also inhibits mammalian fatty acid synthase (FASN), and may have anticarcinogenic activity.

Analysis Note

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Other Notes

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Footnote

To see an example of a Certificate of Analysis for this material enter LRAA9502 in the slot below. This is an example certificate only and may not be the lot that you receive.

Pictograms

Exclamation markEnvironment
GHS07,GHS09

Signal Word

Warning

Hazard Statements

H315,H319,H410

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Triclosan: applications and safety
    Bhargava HN and Leonard PA
    American Journal of Infection Control, 24(3), 209-218 (1996)
    Determination of triclosan in foodstuffs
    Sanches-Silva A, et al.
    Journal of Separation Science, 28(1), 65-72 (2005)
    Joseph V Rodricks et al.
    Critical reviews in toxicology, 40(5), 422-484 (2010-04-10)
    Triclosan (2,4,4'-trichloro-2'-hydroxy-diphenyl ether) is an antibacterial compound that has been used in consumer products for about 40 years. The tolerability and safety of triclosan has been evaluated in human volunteers with little indication of toxicity or sensitization. Although information in
    Gilles Bedoux et al.
    Environmental science and pollution research international, 19(4), 1044-1065 (2011-11-08)
    A review was undertaken on the occurrence, toxicity, and degradation of triclosan (TCS; 5-chloro-2,4-dichlorophenoxy)phenol) in the environment. TCS is a synthetic, broad-spectrum antibacterial agent incorporated in a wide variety of household and personal care products such as hand soap, toothpaste
    Z X Wang et al.
    The British journal of surgery, 100(4), 465-473 (2013-01-23)
    Surgical-site infections (SSIs) increase morbidity and mortality in surgical patients and represent an economic burden to healthcare systems. Experiments have shown that triclosan-coated sutures (TCS) are beneficial in the prevention of SSI, although the results from individual randomized controlled trials
    View All Related Papers

    Protocols

    LC MS Analysis of Triclosan Irgasan in Waste Water

    Separation of Irgasan, ≥97.0% (HPLC)

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