LDLR
low density lipoprotein receptor
Synonyms:
FH, FHC, LDLCQ2
Species:
Human LDLR (3949), Mouse Ldlr (16835), Rat Ldlr (300438), Zebrafish ldlr (387529), dog LDLR (100683160), chicken LDLR (395103), domestic cat LDLR (101080362), cow LDLR (281276), Domestic Rabbit LDLR (100009086), domestic guinea pig Ldlr (100724238)
UniProtKB ID:
Gene ID:
- Human(3949) Summary: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
- Mouse(16835) low density lipoprotein receptor
- Rat(300438) low density lipoprotein receptor
- Zebrafish(387529) low density lipoprotein receptor
- dog(100683160) low density lipoprotein receptor
- chicken(395103) low density lipoprotein receptor
- domestic cat(101080362) low density lipoprotein receptor
- cow(281276) low density lipoprotein receptor
- Domestic Rabbit(100009086) low density lipoprotein receptor
- domestic guinea pig(100724238) low density lipoprotein receptor
- naked mole-rat(101703463) low density lipoprotein receptor
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ELISA
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-LDL Receptor Mouse mAb (15C8), liquid, clone 15C8, Calbiochem®,
Species Reactivity
bovine, human
Application
Anti-Low Density Lipoprotein Antibody, HOCL oxidized, serum, Chemicon®,
Species Reactivity
human
Application
ELISA
immunohistochemistry
immunohistochemistry
Anti-LDLR Antibody, clone C7, clone C7, from mouse,
Species Reactivity
bovine, human
Application
western blot
Anti-LDLR antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-LDL Receptor Antibody, clone 2H7.1, clone 2H7.1, from mouse,
Species Reactivity
human
Application
flow cytometry
immunohistochemistry
western blot
immunohistochemistry
western blot