ERBB2
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
Synonyms:
CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1
Species:
Human ERBB2 (2064), Mouse Erbb2 (13866), Rat Erbb2 (24337), sheep ERBB2 (780519), Domestic Rabbit ERBB2 (100009554), naked mole-rat Erbb2 (101705227), domestic guinea pig Erbb2 (100727657), Zebrafish erbb2 (386966), cow ERBB2 (505709), Horse ERBB2 (100054739) ...More
UniProtKB ID:
Gene ID:
- Human(2064) Summary: This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
- Mouse(13866) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
- Rat(24337) v-erb-b2 avian erythroblastic leukemia viral oncogene 2
- sheep(780519) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
- Domestic Rabbit(100009554) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
- naked mole-rat(101705227) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
- domestic guinea pig(100727657) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
- Zebrafish(386966) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
- cow(505709) v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
- Horse(100054739) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
- domestic cat(751824) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
- dog(403883) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
- chicken(426130) v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog
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ELISA
Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-c-erbB-2 antibody produced in mouse, ~2 mg/mL, clone HER2-96, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunoprecipitation (IP)
microarray
immunoprecipitation (IP)
microarray
Anti-phospho-HER2 (pTyr1221/Tyr1222) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-c-ErbB2/c-Neu (Ab-5) Mouse mAb (TA-1), liquid, clone TA-1, Calbiochem®,
Species Reactivity
human
Application
Anti-ERBB2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Anti-c-ErbB2/c-Neu (Ab-5) Antibody, clone TA-1, clone TA-1, from mouse,
Species Reactivity
human
Application
flow cytometry
immunofluorescence
immunoprecipitation (IP)
western blot
immunofluorescence
immunoprecipitation (IP)
western blot
Cell Lines
Small Molecule - Inhibitor
Proteins
Product Number
Description
Species
HER2 (676-end), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human