DUSP3
dual specificity phosphatase 3
Synonyms:
VHR
Species:
Human DUSP3 (1845), Mouse Dusp3 (72349), Rat Dusp3 (498003), chicken DUSP3 (425527), dog DUSP3 (480505), cow DUSP3 (615432), domestic cat DUSP3 (101083983), sheep DUSP3 (101114374), naked mole-rat Dusp3 (101702703), domestic guinea pig Dusp3 (100730437)
UniProtKB ID:
Gene ID:
- Human(1845) Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008]
- Mouse(72349) dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)
- Rat(498003) dual specificity phosphatase 3
- chicken(425527) dual specificity phosphatase 3
- dog(480505) dual specificity phosphatase 3
- cow(615432) dual specificity phosphatase 3
- domestic cat(101083983) dual specificity phosphatase 3
- sheep(101114374) dual specificity phosphatase 3
- naked mole-rat(101702703) dual specificity phosphatase 3
- domestic guinea pig(100730437) dual specificity phosphatase 3
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-DUSP3 antibody produced in mouse, clone 5B7, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Monoclonal Anti-DUSP3 antibody produced in mouse, clone 5B7, ascites fluid,
Species Reactivity
human
Application
ELISA
western blot
western blot
Monoclonal Anti-DUSP3 antibody produced in mouse, clone 2C4, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
Anti-DUSP3, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-DUSP3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Small Molecule - Inhibitor
Product Number
Description
Species
Proteins
Product Number
Description
Species