Skip to Content
Merck
  • Continuous-flow synthesis of monoarylated acetaldehydes using aryldiazonium salts.

Continuous-flow synthesis of monoarylated acetaldehydes using aryldiazonium salts.

Journal of the American Chemical Society (2012-07-21)
Natalia Chernyak, Stephen L Buchwald
ABSTRACT

Anilines and ethyl vinyl ether can be used as precursors for a process that is the synthetic equivalent of the α-arylation of acetaldehyde enolate. The reaction manifests a high level of functional group compatibility, allowing the ready preparation of a number of synthetically valuable compounds.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Ethyl vinyl ether, contains 0.1% KOH as stabilizer, 99%