A4727
Antisauvagine-30 trifluoroacetate salt
Synonym(s):
Anti-SVG-30, [D-Phe11,His12]-Sauvagine fragment 11-40 trifluoroacetate salt
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About This Item
Empirical Formula (Hill Notation):
C161H274N48O46S
Molecular Weight:
3650.26
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.32
Recommended Products
form
powder
Quality Level
storage temp.
−20°C
Gene Information
human ... CRHR2(1395)
mouse ... CRHR2(12922)
rat ... CRHR2(64680)
Amino Acid Sequence
Phe-His-Leu-Leu-Arg-Lys-Met-Ile-Glu-Ile-Glu-Lys-Gln-Glu-Lys-Glu-Lys-Gln-Gln-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Ile-NH2
Biochem/physiol Actions
High-affinity antagonist for Corticotropin-releasing factor (CRF) receptor type 2 (CRF(2)).
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Nina C Donner et al.
Psychoneuroendocrinology, 63, 178-190 (2015-10-12)
Anxiety and affective disorders are often associated with hypercortisolism and dysfunctional serotonergic systems, including increased expression of TPH2, the gene encoding the rate-limiting enzyme of neuronal serotonin synthesis. We previously reported that chronic glucocorticoid exposure is anxiogenic and increases rat
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