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857410P

Avanti

IG7

Avanti Research™ - A Croda Brand, powder

Synonym(s):

N-((2S,3R)-3-hydroxy-1-oxo-1-(tridecylamino)butan-2-yl)-5-methoxy-1H-indole-2-carboxamide

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About This Item

Empirical Formula (Hill Notation):
C27H43N3O4
CAS Number:
2132345-13-0
Molecular Weight:
473.65
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

99% (TLC)

form

powder

packaging

pkg of 1 × 1 mg (857410P-5mg)
pkg of 1 × 5 mg (857410P-5mg)

manufacturer/tradename

Avanti Research™ - A Croda Brand

lipid type

bioactive lipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

C[C@@H](O)[C@H](NC(C(N1)=CC2=C1C=CC(OC)=C2)=O)C(NCCCCCCCCCCCCC)=O

General description

IG7 is a ceramide analog.

Biochem/physiol Actions

IG7 is potent in enhancing Fas ligand (FasL) induced apoptosis in colon carcinoma cells SW480 and RKO. IG7 enhances FasL mediated phosphorylation of p38 and janus kinase (JNK). IG7 enhances nuclear factor-kappa B (NF-κB) activation by FasL. IG7 exhibits low toxicity.

Packaging

5ML Glass Amber Screw Cap Vial (857410P-1MG)
5ML Glass Amber Screw Cap Vial (857410P-5MG)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ceramide mediates FasL-induced caspase 8 activation in colon carcinoma cells to enhance FasL-induced cytotoxicity by tumor-specific cytotoxic T lymphocytes
Coe GL, et al.
Scientific Reports, 6, 30816-30816 (2016)

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