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Merck

C4B

complement component 4B (Chido blood group)

Synonyms:
C4B1, C4B12, C4B2, C4B3, C4B5, C4BD, C4B_2, C4F, CH, CO4, CPAMD3
Species:
Human C4B (721), Mouse C4b (12268), Rat C4b (406161), cow C4B (100851057), domestic cat C4B (101094346)
UniProtKB ID:
P0C0L5, A2BHY4, P01028, P78445, Q13160, Q13906, Q14033, Q14835
Gene ID:
  • Human(721) Summary: This gene encodes the basic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 kb endogenous HERV-K retrovirus in intron 9. [provided by RefSeq, Jul 2008]
  • Mouse(12268) complement component 4B (Chido blood group)
  • Rat(406161) complement component 4B (Chido blood group)
  • cow(100851057) complement component 4B (Chido blood group)
  • domestic cat(101094346) complement component 4B (Chido blood group)

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB2100304
Anti-C4B antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
horse, human
Application
western blot
SAB1403623
Monoclonal Anti-C4B antibody produced in mouse, clone 1F2, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
western blot
SAB5500020
Anti-C4D antibody, Rabbit monoclonal, recombinant, expressed in proprietary host, clone SP91, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry
MABF2819
Anti-Complement C4B Antibody, clone 16D2, ,
Species Reactivity
mouse
Application
ELISA
immunofluorescence
immunohistochemistry
western blot