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  • Three-component synthesis of functionalized 5-oxo-4,5-dihydroindeno[1,2-b]pyrans.

Three-component synthesis of functionalized 5-oxo-4,5-dihydroindeno[1,2-b]pyrans.

Molecular diversity (2006-06-17)
Issa Yavari, Mehdi Sirouspour, Sanaz Souri
ABSTRACT

Protonation of the reactive intermediates produced in the reaction between alkyl(aryl) isocyanides and dialkyl acetylenedicarboxylates by indan-1,3-dione leads to vinylnitrilium cations, which undergo carbon centered Michael type addition with the conjugate base of the CH-acid to produce functionalized 5-oxo-4,5-dihydroindeno[1,2-b]pyrans.

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Acetylenedicarboxylic acid, 95%
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Sigma-Aldrich
Acetylenedicarboxylic acid monopotassium salt, ≥98%
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