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213535

Sigma-Aldrich

2,4-Dichloro-6-methoxy-1,3,5-triazine

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About This Item

Empirical Formula (Hill Notation):
C4H3Cl2N3O
CAS Number:
3638-04-8
Molecular Weight:
179.99
EC Number:
222-863-4
MDL number:
MFCD00128159
UNSPSC Code:
12352100
PubChem Substance ID:
24852788
NACRES:
NA.22

Quality Level

100

bp

132-134 °C/49 mmHg (lit.)

mp

86-88 °C (lit.)

SMILES string

COc1nc(Cl)nc(Cl)n1

InChI

1S/C4H3Cl2N3O/c1-10-4-8-2(5)7-3(6)9-4/h1H3

InChI key

JKAPWXKZLYJQJJ-UHFFFAOYSA-N

Application

2,4-Dichloro-6-methoxy-1,3,5-triazine was used as reagent in radioimmunoassay for D-Ala2-Dermorphin, a natural peptide extracted from amphibian skin. It was also used in the preparation of:




  • α-cyclodextrin [2]-rotaxanes
  • substituted s-triazines
  • series of chiral derivatizing reagents

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ryan E Dawson et al.
Organic & biomolecular chemistry, 6(10), 1814-1821 (2008-05-03)
Ten alpha-cyclodextrin [2]-rotaxanes have been prepared with alkane-, stilbene- and azobenzene-based axles, capped through nucleophilic substitution of either 2-chloro-4,6-dimethoxy-1,3,5-triazine or 2,4-dichloro-6-methoxy-1,3,5-triazine in aqueous solution, followed by further substitution of the remaining triazinyl chlorine in some cases when the latter capping
H Brückner et al.
Journal of chromatography. A, 998(1-2), 73-82 (2003-07-17)
A series of chiral derivatizing reagents (CDRs) was synthesized by nucleophilic replacement of one chlorine atom in cyanuric chloride (2,4,6-trichloro-1,3,5-triazine; s-triazine) by alkoxy (methoxy, butoxy, 1,1,1-trifluoroethoxy) or aryloxy groups (phenoxy, nitrophenoxy, phenylphenoxy, 4-methylcoumaryloxy), and displacement of a second chlorine by
L Negri et al.
Peptides, 2 Suppl 2, 45-49 (1981-01-01)
A selective RIA for D-Ala2-Dermorphin (Der), a natural peptide extracted from amphibian skin, has been developed using an antibody raised in rabbits against Der which has been coupled to BSA through its phenolic hydroxyl groups of tyrosine residues with 2,4-Dichloro-6-methoxy-1,3,5-triazine.
Recent applications of 2, 4, 6-trichloro-1, 3, 5-triazine and its derivatives in organic synthesis.
Blotny G.
Tetrahedron, 62(41), 9507-9522 (2006)
Tatsuki Nakano et al.
Analytica chimica acta, 880, 145-151 (2015-06-21)
In this study, a novel pre-column excimer fluorescence derivatization reagent, 2-chloro-4-methoxy-6-(4-(pyren-4-yl)butoxy)-1,3,5-triazine (CMPT), was developed for polyamines, specifically histamine. By CMPT derivatization, the polyamines, histamine and tyramine were converted to polypyrene derivatives, and emitted intra-molecular excimer fluorescence at 475nm. This could

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