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Merck

XRCC5

X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)

Synonyms:
KARP-1, KARP1, KU80, KUB2, Ku86, NFIV
Species:
UniProtKB ID:
Gene ID:
  • Human(7520) Summary: The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
  • Mouse(22596) X-ray repair complementing defective repair in Chinese hamster cells 5
  • Rat(363247) X-ray repair complementing defective repair in Chinese hamster cells 5
  • sheep(101107255) X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
  • domestic guinea pig(100728001) X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
  • naked mole-rat(101719341) X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
  • Domestic Rabbit(100347656) X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
  • Zebrafish(449848) X-ray repair complementing defective repair in Chinese hamster cells 5
  • Horse(100055031) X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
  • domestic cat(101083534) X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
  • dog(478902) X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
  • chicken(424222) X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)

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Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-XRCC5 antibody produced in mouse, clone 3D8, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence

western blot
Anti-Ku80 antibody produced in rabbit, ,
Species Reactivity
Application
immunohistochemistry
western blot
Anti-XRCC5/Ku80 Antibody, clone 1C9 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, monkey
Application
immunocytochemistry
immunohistochemistry

western blot
Anti-XRCC5 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry

immunoprecipitation (IP)

western blot
Anti-XRCC5 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting mouse Xrcc5,
Species
mouse
MISSION® esiRNA, targeting human XRCC5,
Species
human