ATM
ataxia telangiectasia mutated
Synonyms:
AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1
Species:
Human ATM (472), Mouse Atm (11920), Rat Atm (300711), Zebrafish atm (403064), cow ATM (526824), Horse ATM (100061765), domestic cat ATM (101089291), dog ATM (479450), chicken ATM (395401), Thale Cress ATM (823975) ...More
UniProtKB ID:
Gene ID:
- Human(472) Summary: The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010]
- Mouse(11920) ataxia telangiectasia mutated homolog (human)
- Rat(300711) ataxia telangiectasia mutated
- Zebrafish(403064) ataxia telangiectasia mutated
- cow(526824) ataxia telangiectasia mutated
- Horse(100061765) ataxia telangiectasia mutated
- domestic cat(101089291) ataxia telangiectasia mutated
- dog(479450) ataxia telangiectasia mutated
- chicken(395401) ataxia telangiectasia mutated
- Thale Cress(823975) serine/threonine-protein kinase ATM
- naked mole-rat(101718948) ataxia telangiectasia mutated
- domestic guinea pig(100717983) ataxia telangiectasia mutated
- sheep(101105847) ataxia telangiectasia mutated
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-ATM antibody produced in mouse, clone 2C10, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
immunofluorescence
Anti-p-ATM (Ser1981) Antibody, clone 1E19, ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human
Application
affinity binding assay
immunohistochemistry
inhibition assay
western blot
immunohistochemistry
inhibition assay
western blot
Anti-ATM antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Anti-ATM antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-phospho-ATM (Ser1981) Antibody, clone 10H11.E12, Alexa Fluor™ 488, clone 10H11.E12, from mouse, ALEXA FLUOR™ 488,
Species Reactivity
human, mouse
Application
immunocytochemistry
Proteins
Product Number
Description
Species