SML1271

TWS119

≥98% (HPLC)

• Synonym(e): 3-[6-(3-Aminophenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy]phenol
• Empirische Formel (Hill-System): C₁₈H₁₄N₄O₂
• CAS-Nummer: 601514-19-6
• Molekulargewicht: 318.33
• MDL-Nummer: MFCD09037535
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825758
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 20 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: OC1=CC(OC2=NC=NC3=C2C=C(C4=CC=CC(N)=C4)N3)=CC=C1
• InChI: 1S/C18H14N4O2/c19-12-4-1-3-11(7-12)16-9-15-17(22-16)20-10-21-18(15)24-14-6-2-5-13(23)8-14/h1-10,23H,19H2,(H,20,21,22)
• InChIKey: VPVLEBIVXZSOMQ-UHFFFAOYSA-N

Beschreibung

Anwendung

TWS119 has been used as glycogen synthase kinase-3β (GSK-3β) GSK3β inhibitor.

Biochem./physiol. Wirkung

TWS119 favors the γδT cells survival and proliferation by activating the mammalian target of rapamycin (mTOR) pathway. It also promotes the expression of T-cell factor 1 (TCF1) and modulates cytokine production.

TWS119 is a potent Glycogen synthase kinase-3β (GSK-3β) inhibitor that can induce neurogenesis in embryonic stem cells (ESCs).

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3