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SML1044

Sigma-Aldrich

Zosuquidar hydrochloride

≥98% (HPLC), powder, p-Glycoprotein inhibitor

Synonym(e):

(2R)-Anti-5-[3-[4-(10,11-difluoromethanodibenzosuber-5-yl)piperazin-1-yl]-2-hydroxypropoxy]quinoline hydrochloride, LY-335979, RS-33295-198

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About This Item

Empirische Formel (Hill-System):
C32H31F2N3O2 · xHCl
CAS-Nummer:
167354-41-8
Molekulargewicht:
527.60 (free base basis)
UNSPSC-Code:
12161501
PubChem Substanz-ID:
329825638
NACRES:
NA.77

product name

Zosuquidar hydrochloride, ≥98% (HPLC)

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

powder

Lagerbedingungen

desiccated

Farbe

white to beige

Löslichkeit

H2O: 4 mg/mL, clear (warmed)

Lagertemp.

−20°C

SMILES String

O[C@@H](COC1=C(C=CC=N2)C2=CC=C1)CN(CC3)CCN3[C@@H]4C5=C(C=CC=C5)[C@@H]6[C@@H](C6(F)F)C7=C4C=CC=C7.Cl

InChI

1S/C32H31F2N3O2.ClH/c33-32(34)29-22-7-1-3-9-24(22)31(25-10-4-2-8-23(25)30(29)32)37-17-15-36(16-18-37)19-21(38)20-39-28-13-5-12-27-26(28)11-6-14-35-27;/h1-14,21,29-31,38H,15-20H2;1H/t21-,29-,30+,31-;/m1./s1

InChIKey

VQJFFWJUYDGTQZ-FCNWNIDBSA-N

Biochem./physiol. Wirkung

Zosuqidar is a potent inhibitor of P-glycoprotein (P-gp, MDR1) a transporter protein that is a key modulator of cellular drug efflux. Zosuquidar sensitizes AML, and other cancer cell lines to cytotoxic drugs.

Leistungsmerkmale und Vorteile

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Yoko Nagaya et al.
Drug metabolism and disposition: the biological fate of chemicals, 48(11), 1183-1190 (2020-08-31)
Estimation of unbound drug concentration in the brain (Cu,brain) is an essential part of central nervous system (CNS) drug development. As a surrogate for Cu,brain in humans and nonhuman primates, drug concentration in cerebrospinal fluid (CCSF) collected by lumbar puncture
J Vérité et al.
Journal of neuroinflammation, 15(1), 182-182 (2018-06-15)
Alzheimer's disease is widely described since the discovery of histopathological lesions in Mrs. Auguste Deter in 1906. However to date, there is no effective treatment to deal with the many cellular and molecular alterations. The complexity is even higher with
Kamil Nosol et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(42), 26245-26253 (2020-10-07)
ABCB1 detoxifies cells by exporting diverse xenobiotic compounds, thereby limiting drug disposition and contributing to multidrug resistance in cancer cells. Multiple small-molecule inhibitors and inhibitory antibodies have been developed for therapeutic applications, but the structural basis of their activity is

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