SML0025

Safinamide mesylate salt

≥98% (HPLC)

• Synonym(e): (S)-(+)-2-[[4-(3-Fluorobenzoxy)benzyl]amino]propanamide; (S)-2-[[4-[(3-Fluorobenzyl)oxy]benzyl]amino]propanamide; FCE-26743; PNU-151774E, NW-1015;
• Empirische Formel (Hill-System): C₁₇H₁₉FN₂O₂ · xCH₄O₃S
• CAS-Nummer: 202825-46-5
• Molekulargewicht: 302.34 (free base basis)
• MDL-Nummer: MFCD15145475
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825096
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Optische Aktivität: [α]/D +9.5 to +14°, c = 1 (95% acetic acid)
• Farbe: white to tan
• Löslichkeit: H₂O: ≥15 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: CS(O)(=O)=O.C[C@H](NCc1ccc(OCc2cccc(F)c2)cc1)C(N)=O
• InChI: 1S/C17H19FN2O2.CH4O3S/c1-12(17(19)21)20-10-13-5-7-16(8-6-13)22-11-14-3-2-4-15(18)9-14;1-5(2,3)4/h2-9,12,20H,10-11H2,1H3,(H2,19,21);1H3,(H,2,3,4)/t12-;/m0./s1
• InChIKey: YKOCHIUQOBQIAC-YDALLXLXSA-N
• Angaben zum Gen: human ... MAOB(4129)

Beschreibung

Anwendung

Safinamide mesylate salt has been used as a reference drug to study its inhibitory effect on human monoamine oxidases (hMAO-A and hMAO-B).

Safinamide mesylate salt may be used in cell signaling studies.

Biochem./physiol. Wirkung

Safinamide is a highly selective and reversible monoamine oxidase type B (MAO-B) inhibitor that increases neostriatal dopamine concentration. In addition, safinamide is voltage-dependent sodium and calcium channel blocker. It appears to bind to the batrachotoxin-sensitive site 2 of the voltage-sensitive sodium channels. Safinamide blocks N and L-type calcium channels and inhibits glutamate and aspartate release from synaptic terminals.

Safinamide mesylate prevents dopamine reuptake and is effective in the treatment of epilepsy and Parkinson′s disease.

Leistungsmerkmale und Vorteile

This compound is featured on the Calcium Channels and Dopamine and Norepinephrine Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS08,GHS07
• Signalwort: Warning
• H-Sätze: H302,H319,H361d
• P-Sätze: P202 - P264 - P270 - P301 + P312 - P305 + P351 + P338 - P308 + P313
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable