P8013

Pargylin -hydrochlorid

• Synonym(e): N-Methyl-N-(2-propinyl)benzylamin -hydrochlorid, N-Methyl-N-propargylbenzylamin -hydrochlorid
• Lineare Formel: C₆H₅CH₂N(CH₃)CH₂C≡CH·HCl
• CAS-Nummer: 306-07-0
• Molekulargewicht: 195.69
• Beilstein: 3699487
• EG-Nummer: 206-175-1
• MDL-Nummer: MFCD00012492
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278153
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: synthetic
• Assay: 98% (TLC)
• Form: powder or crystals
• mp (Schmelzpunkt): 160-163 °C (lit.)
• Löslichkeit: water: 50 mg/mL, clear, colorless to faintly yellow
• Lagertemp.: −20°C
• SMILES String: Cl[H].CN(CC#C)Cc1ccccc1
• InChI: 1S/C11H13N.ClH/c1-3-9-12(2)10-11-7-5-4-6-8-11;/h1,4-8H,9-10H2,2H3;1H
• InChIKey: BCXCABRDBBWWGY-UHFFFAOYSA-N
• Angaben zum Gen: human ... MAOA(4128) , MAOB(4129)

Beschreibung

Anwendung

Pargyline hydrochloride has been used:

• as a histone demethylase inhibitor to treat monocytes to investigate whether various inhibitors affect training
• to maximize uptake into dopaminergic neurons (DA) neurons in experimental rats,
• to study its effect on discolouration of medullary tissues of sclerotia of S. sclerotiorum

Biochem./physiol. Wirkung

Pargyline hydrochloride acts as a histone demethylase inhibitor. It has antihypertensive action.

Selektiver MAO-B-Inhibitor.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301
• P-Sätze: P301 + P310
• Gefahreneinstufungen: Acute Tox. 3 Oral
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves