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P6500

Sigma-Aldrich

Pentylentetrazol

≥99% (GC), powder, CNS stimulant

Synonym(e):

α,β-Cyclopentamethylenetetrazole, 1,5-Pentamethylenetetrazole, 6,7,8,9-Tetrahydro-5H-tetrazolo[1,5-a]azepine, Metrazole

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About This Item

Empirische Formel (Hill-System):
C6H10N4
CAS-Nummer:
54-95-5
Molekulargewicht:
138.17
EG-Nummer:
200-219-3
MDL-Nummer:
MFCD00005939
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24278643
NACRES:
NA.77

product name

Pentylentetrazol,

Form

powder

bp

194 °C/12 mmHg (lit.)

mp (Schmelzpunkt)

59-61 °C (lit.)

Lagertemp.

−20°C

SMILES String

C1CCc2nnnn2CC1

InChI

1S/C6H10N4/c1-2-4-6-7-8-9-10(6)5-3-1/h1-5H2

InChIKey

CWRVKFFCRWGWCS-UHFFFAOYSA-N

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Allgemeine Beschreibung

Pentylenetetrazole (PTZ) is a tetrazole derivative and inhibitor of the γ aminobutyric acid (GABAA) and its receptor complex. PTZ is a convulsing agent used for inducing seizures. It can traverse the blood-brain barrier.

Anwendung

Pentylenetetrazole has been used to induce seizures in zebra fish larvae, mice, and male wistar rats.

Biochem./physiol. Wirkung

Pentylenetetrazole is a non-specific central nervous system (CNS) stimulant and convulsant. PTZ induces oxidative stress and increases cortical malondialdehyde content and affects hippocampus, resulting in seizures.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Effects of bee products on pentylenetetrazole-induced seizures in the rat
Zarraga-Galindo N, et al.
Proceedings of the Western Pharmacology Society, 54, 33-40 (2011)
Central nervous system uptake kinetics of pentylenetetrazol in the developing rat
Haberer LJ and Pollack GM
Biopharmaceutics & Drug Disposition, 12(1), 59-71 (1991)
Tatiana Afrikanova et al.
PloS one, 8(1), e54166-e54166 (2013-01-24)
Zebrafish have recently emerged as an attractive in vivo model for epilepsy. Seven-day-old zebrafish larvae exposed to the GABA(A) antagonist pentylenetetrazol (PTZ) exhibit increased locomotor activity, seizure-like behavior, and epileptiform electrographic activity. A previous study showed that 12 out of
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Eclipta alba (Linn) Hassk. (Asteraceae) has been reported to be a nerve tonic and has been used to treat epilepsy in folk medicine. The present study isolates and characterizes luteolin from E. alba and evaluates its antiepileptic potential in chemically
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 84, 962-971 (2016-10-21)
Diabetic neuropathy is the most prevalent, persistent and debilitating complication of diabetes mellitus often coupled with vulvodynia that may present as an isolated symptom or as a part of constellation of other neuropathic abnormalities. Flavonoids have selective affinity for GABA
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