N8159
Albumin, Nitrated from bovine serum
lyophilized powder
Synonym(e):
Nitrated BSA
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About This Item
Empfohlene Produkte
Biologische Quelle
bovine
Qualitätsniveau
Form
lyophilized powder
Methode(n)
immunoblotting: suitable
UniProt-Hinterlegungsnummer
Versandbedingung
wet ice
Lagertemp.
−20°C
Angaben zum Gen
bovine ... ALB(280717)
Allgemeine Beschreibung
Albumin, Nitrated (Nitrated BSA), is prepared by chemical modification of bovine serum albumin (BSA) by peroxynitrite. Peroxynitrite (ONOO-), a potent oxidant is an important member of the family of reactive oxygen and nitrogen species.
Anwendung
Positive control in immunoblotting assays for Anti-Nitrotyrosine (Sigma Product Number N 0409).
Biochem./physiol. Wirkung
Peroxynitrite promotes the nitration of tyrosine residues in proteins linked, oxidation of redox metal centers, DNA, lipids and nitrosation of cysteine residues in proteins, suggesting that peroxynitrite plays a major role in oxidative cellular damage. Peroxynitrite has been implicated in the pathogenesis of several inflammatory, infectious and degenerative human disease. These include neurological conditions such as Alzheimer′s disease, amyotrophic lateral sclerosis (ALS), the pathogenesis of asthma, atherosclerosis, and a variety of conditions precipitated by endothelial injury.
Physikalische Form
Lyophilized from 0.01 M phosphate buffered saline, pH 7.4
Angaben zur Herstellung
Bovine serum albumin (BSA) nitrated with peroxynitrite.
Hinweis zur Analyse
Does not contain sodium azide
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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Lai H and Yen GC
Bioscience, Biotechnology, and Biochemistry, 66(1), 22-28 (2002)
The Intracellular Redox Stress Caused by Hexavalent Chromium is Selective for Proteins that Have Key Roles in Cell Survival and Thiol Redox Control
Judith M
Toxicology (2011)
Nitric oxide and peroxynitrite in health and disease
Pacher P, et al.
Physiological Reviews, 87(1), 315-424 (2007)
Péter Borbély et al.
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