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Merck

G1001

Sigma-Aldrich

D-Glutaminsäure

≥99% (TLC), suitable for ligand binding assays

Synonym(e):

(R)-2-Amino-glutarsäure, (R)-2-Aminopentandisäure, D-Glu, R-(−)-1-Aminopropan-1,3-dicarbonsäure

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About This Item

Lineare Formel:
HO2CCH2CH2CH(NH2)CO2H
CAS-Nummer:
Molekulargewicht:
147.13
Beilstein:
1723800
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352209
PubChem Substanz-ID:
NACRES:
NA.32

product name

D-Glutaminsäure, ≥99% (TLC)

Assay

≥99% (TLC)

Form

powder

Methode(n)

ligand binding assay: suitable

Farbe

white to off-white

mp (Schmelzpunkt)

200-202 °C (subl.) (lit.)

SMILES String

N[C@H](CCC(O)=O)C(O)=O

InChI

1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m1/s1

InChIKey

WHUUTDBJXJRKMK-GSVOUGTGSA-N

Angaben zum Gen

human ... CCR2(1231)

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Allgemeine Beschreibung

D-Glutamic acid is an essential constituent of the bacterial peptidoglycan structure. It is added to UDP-N-acetylmuramyl-L-alanine (UDP-MurNAc-L-alanine) by the enzyme D-glutamic acid-adding enzyme (murD). This is, then, incorporated into the peptidoglycan precursor. Peptidoglycan makes up the cell walls of Gram-positive and -negative bacteria. The conversion of L-glutamate to D-glutamate by glutamate racemase (GR) enzyme is an essential step in the synthesis of peptidoglycan.

Anwendung

D-glutamic acid is suitable for use in the structure-affinity relationship (SAR)-study of GR (glutamate racemase) enzyme and its inhibitors.

Biochem./physiol. Wirkung

unnatürliches Glutaminsäure-Isomer

Anwendung

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


Analysenzertifikate (COA)

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P Doublet et al.
Journal of bacteriology, 174(18), 5772-5779 (1992-09-01)
The murI gene of Escherichia coli, whose inactivation results in the inability to form colonies in the absence of D-glutamic acid, was identified in the 90-min region of the chromosome. The complementation of an auxotrophic E. coli B/r strain by
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H Persson et al.
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The gene encoding glutamic acid decarboxylase (GAD), the key enzyme in the synthesis of the inhibitory neurotransmitter gamma-aminobutyric acid, is shown to be expressed in the testis of several different species. Nucleotide sequence analysis of a cDNA clone isolated from
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Science (New York, N.Y.), 298(5592), 425-429 (2002-10-12)
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