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56968

Sigma-Aldrich

Sparfloxacin

≥98.0% (HPLC)

Synonym(e):

5-Amino-1-cyclohexyl-7-(cis-3,5-dimethylpiperazino)-6,8-difluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure

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About This Item

Empirische Formel (Hill-System):
C19H22F2N4O3
CAS-Nummer:
110871-86-8
Molekulargewicht:
392.40
Beilstein:
9170271
MDL-Nummer:
MFCD00869619
UNSPSC-Code:
51282944
PubChem Substanz-ID:
57651613
NACRES:
NA.85

Biologische Quelle

synthetic

Assay

≥98.0% (HPLC)

Form

powder

Farbe

white to light yellow

Wirkungsspektrum von Antibiotika

Gram-negative bacteria
Gram-positive bacteria
mycobacteria
mycoplasma

Wirkungsweise

enzyme | inhibits

SMILES String

C[C@H]1CN(C[C@@H](C)N1)c2c(F)c(N)c3C(=O)C(=CN(C4CC4)c3c2F)C(O)=O

InChI

1S/C19H22F2N4O3/c1-8-5-24(6-9(2)23-8)17-13(20)15(22)12-16(14(17)21)25(10-3-4-10)7-11(18(12)26)19(27)28/h7-10,23H,3-6,22H2,1-2H3,(H,27,28)/t8-,9+

InChIKey

DZZWHBIBMUVIIW-DTORHVGOSA-N

Angaben zum Gen

human ... KCNH1(3756) , TOP2A(7153)

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Verwandte Kategorien

Anwendung

Sparfoxacin is used to study antimicrobial activity against Mycobacteria and respiratory tract infections .

Biochem./physiol. Wirkung

Sparfloxacin fluoroquinolone antibiotic that inhibits bacterial DNA gyrase (topoisomerase II) and/or topoisomerase IV. It inhibits bacterial DNA gyrase-dependent processes such as DNA polymerization, ATP-dependent-DNA supercoiling, and chromosome fragmentation.

Verpackung

1g, 10g

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.Storage class (TRGS 510): Non Combustible Solids

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Ciprofloxacin ≥98% (HPLC)

Sigma-Aldrich

17850

Ciprofloxacin

Ofloxacin fluoroquinolone antibiotic

Sigma-Aldrich

O8757

Ofloxacin

Nitrofurantoin 98.0-102.0% (EP, UV)

Sigma-Aldrich

N7878

Nitrofurantoin

Oxytetracyclin -hydrochlorid

Sigma-Aldrich

O5875

Oxytetracyclin -hydrochlorid

K L Goa et al.
Drugs, 53(4), 700-725 (1997-04-01)
Sparfloxacin is a fluoroquinolone antibacterial agent with activity against a broad range of Gram-negative and Gram-positive organisms including Streptococcus pneumoniae, one of the main pathogens in community-acquired pneumonia. In this infection, sparfloxacin has shown efficacy similar to that of amoxicillin
N Rastogi et al.
Antimicrobial agents and chemotherapy, 35(12), 2473-2480 (1991-12-01)
The MICs and MBCs of the new difluorinated quinolone drug sparfloxacin against type strains belonging to 21 species of mycobacteria were screened. The MICs and MBCs were within the range of 0.1 to 2.0 and 0.1 to 4.0 micrograms/ml, respectively
Radha K Shandil et al.
Antimicrobial agents and chemotherapy, 51(2), 576-582 (2006-12-06)
Members of the fluoroquinolone class are being actively evaluated for inclusion in tuberculosis chemotherapy regimens, and we sought to determine the best in vitro and pharmacodynamic predictors of in vivo efficacy in mice. MICs for Mycobacterium tuberculosis H37Rv were 0.1
Stéphanie Arsène et al.
Antimicrobial agents and chemotherapy, 51(9), 3254-3258 (2007-07-11)
Fluoroquinolones are poorly active against enterococci. Recently, plasmid-borne resistance to fluoroquinolones due to the qnr gene was reported in members of the Enterobacteriaceae family. The gene encodes a pentapeptide repeat protein that protects DNA gyrase from inhibition by fluoroquinolones. We
Joëlle Azéma et al.
Bioorganic & medicinal chemistry, 17(15), 5396-5407 (2009-07-15)
Ciprofloxacin (CP), an antibiotic has been shown to have antiproliferative and apoptotic activities in several cancer cell lines. Moreover, several reports have highlighted the interest of increasing the lipophilicity to improve the antitumor efficacy. These studies have led us to
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