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C9231

Sigma-Aldrich

Carbenicillin Dinatrium

meets USP testing specifications

Synonym(e):

Carbenicillin Dinatriumsalz, α-Carboxybenzylpenicillin Dinatriumsalz

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About This Item

Empirische Formel (Hill-System):
C17H16N2Na2O6S
CAS-Nummer:
4800-94-6
Molekulargewicht:
422.36
Beilstein:
5722128
EG-Nummer:
225-360-8
MDL-Nummer:
MFCD00077683
UNSPSC-Code:
51102829
PubChem Substanz-ID:
24893142
NACRES:
NA.76

Agentur

USP/NF
meets USP testing specifications

Qualitätsniveau

200

Form

solid

Löslichkeit

H2O: 50 mg/mL

Wirkungsspektrum von Antibiotika

Gram-negative bacteria
Gram-positive bacteria

Anwendung(en)

pharmaceutical (small molecule)

Wirkungsweise

cell wall synthesis | interferes

Lagertemp.

2-8°C

SMILES String

[Na+].[Na+].CC1(C)S[C@@H]2[C@H](NC(=O)C(C([O-])=O)c3ccccc3)C(=O)N2[C@H]1C([O-])=O

InChI

1S/C17H18N2O6S.2Na/c1-17(2)11(16(24)25)19-13(21)10(14(19)26-17)18-12(20)9(15(22)23)8-6-4-3-5-7-8;;/h3-7,9-11,14H,1-2H3,(H,18,20)(H,22,23)(H,24,25);;/q;2*+1/p-2/t9?,10-,11+,14-;;/m1../s1

InChIKey

RTYJTGSCYUUYAL-YCAHSCEMSA-L

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Allgemeine Beschreibung

Chemical structure: ß-lactam

Anwendung

Used for selection of ampr transformed cells. Used to study the role of penicillin-sensitive transpeptidases in cell wall biosynthesis.

Biochem./physiol. Wirkung

Wirkungsweise: Carboxypenicillin ist ein Antibiotikum, das die Zellwandsynthese von Bakterien hemmt (Peptidoglykan-Vernetzung), indem es Transpeptidasen auf der Innenfläche der Zellmembran von Bakterien deaktiviert.


Antimikrobielles Spektrum: aktiv gegen grampositive und gramnegative Bakterien

Hinweis zur Analyse

Bei 37 °C 3 Tage lang stabil

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place.

Piktogramme

Health hazard
GHS08

Signalwort

Danger

H-Sätze

H317,H334

Gefahreneinstufungen

Resp. Sens. 1 - Skin Sens. 1

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Analysenzertifikate (COA)

Lot/Batch Number
0000080225
0000080224
0000080223
059M4779V
108M4839V

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Die Dokumentenbibliothek aufrufen

Olivier Fisette et al.
Biophysical journal, 103(8), 1790-1801 (2012-10-23)
The effects of substrate binding on class A β-lactamase dynamics were studied using molecular dynamics simulations of two model enzymes; 40 100-ns trajectories of the free and substrate-bound forms of TEM-1 (with benzylpenicillin) and PSE-4 (with carbenicillin) were recorded (totaling
Nina Möker et al.
Journal of bacteriology, 192(7), 1946-1955 (2010-01-26)
Bacterial persister cells constitute a small portion of a culture which is tolerant to killing by lethal doses of bactericidal antibiotics. These phenotypic variants are formed in numerous bacterial species, including those with clinical relevance like the opportunistic pathogen Pseudomonas
John R Zupan et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(22), 9060-9065 (2013-05-16)
Growth and cell division in rod-shaped bacteria have been primarily studied in species that grow predominantly by peptidoglycan (PG) synthesis along the length of the cell. Rhizobiales species, however, predominantly grow by PG synthesis at a single pole. Here we
Sarah Sainsbury et al.
Journal of molecular biology, 405(1), 173-184 (2010-10-27)
We report the first crystal structures of a penicillin-binding protein (PBP), PBP3, from Pseudomonas aeruginosa in native form and covalently linked to two important β-lactam antibiotics, carbenicillin and ceftazidime. Overall, the structures of apo and acyl complexes are very similar;
Edward Avilés et al.
Organic letters, 12(22), 5290-5293 (2010-10-23)
Monamphilectine A (1), a new diterpenoid β-lactam alkaloid showing potent antimalarial activity, was isolated in milligram quantities following bioassay-directed extraction of a Puerto Rican marine sponge Hymeniacidon sp. Its structure, established by interpretation of spectral data, was confirmed unequivocally by
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