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AG723-M

Sigma-Aldrich

C-Reactive Protein

Synonym(e):

CRP

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About This Item

UNSPSC-Code:
12352202
eCl@ss:
32160405
NACRES:
NA.41

Biologische Quelle

human

Qualitätsniveau

100
300

Assay

>98% (SDS-PAGE)

Form

liquid

Hersteller/Markenname

Chemicon®

Konzentration

3.5 mg/mL

NCBI-Hinterlegungsnummer

NM_000567.2

UniProt-Hinterlegungsnummer

P02741

Allgemeine Beschreibung

C-reactive protein (CRP) is a homopentameric acute-phase inflammatory protein, which belongs to the pentraxin family. It is a highly conserved plasma protein produced mainly in liver hepatocytes. It is also synthesized by lymphocytes, smooth muscle cells, macrophages, endothelial cells, and adipocytes.

Anwendung

C-reactive protein (CRP) has been used:
  • as a model analyte for interference-reduced detection of CRP in serum using non-competitive sandwich immunoassay in combination with surface plasmon field-enhanced fluorescence spectroscopy (SPFS)
  • to determine the involvement of collectin placenta 1 (CL-P1) in CRP-mediated complement activation and to investigate the downstream effects of this complement activation
  • to examine to study the effects of lectin-like oxidized low-density lipoprotein receptor 1 (LOX-1) on CRP-induced complement activation by interacting with CRP to develop an inflammatory pathogenic response

Biochem./physiol. Wirkung

C-reactive protein (CRP) plays a vital role in the complement pathway, apoptosis, phagocytosis, nitric oxide (NO) release. It also regulates the production of interleukin-6 and tumor necrosis factor-α. Patients suffering from appendicitis, cholecystitis, pancreatitis, and meningitis have elevated levels of CRP. CRP facilitates the uptake of low-density lipoprotein in macrophages. It has a crucial role in the pathophysiology of cardiovascular disease, which makes it a useful marker for inflammation and cardiovascular events.

Qualität

No precipitin bands when tested at 2 mg/mL against anti-whole human serum.

Physikalische Form

Liquid in 100mM NaCl, 10mM Tris-HCl with 0.1% sodium azide, 2mM CaCl2

Lagerung und Haltbarkeit

Maintain under sterile conditions at 2-8°C for up to one year. Do not freeze. Full safety precautions should be taken as in the handling of any potentially infective body fluid.

Rechtliche Hinweise

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Lagerklassenschlüssel

12 - Non Combustible Liquids

WGK

nwg

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Die Dokumentenbibliothek aufrufen

Lectin-like Oxidized LDL Receptor 1 Is Involved in CRP-Mediated Complement Activation.
Fujita Y, Yamaguchi S, Kakino A, Iwamoto S, Yoshimoto R, Sawamura T.
Clinical Chemistry null
Yoshiko Fujita et al.
Clinical chemistry, 56(3), 478-481 (2010-01-16)
C-reactive protein (CRP) increases in response to inflammation and is purported to be a risk factor for atherogenesis. We recently demonstrated that a scavenger receptor, lectin-like oxidized LDL receptor (LOX-1), is a receptor for CRP. In light of the overlapping
Charles R Kiefer et al.
Clinica chimica acta; international journal of clinical chemistry, 413(19-20), 1536-1541 (2012-06-28)
We evaluated the utility of an independent biomarker of early ischemic cellular damage-circulating fractional forms of C-reactive protein (fracCRP), to verify the diagnostic relevance of low Troponin I (TnI) values within the context of a workup for Acute Coronary Syndrome
Nitai Roy et al.
Biochimica et biophysica acta, 1860(6), 1118-1128 (2016-03-01)
C-reactive protein (CRP) is a plasma pentraxin family protein that is massively induced as part of the innate immune response to infection and tissue injury. CRP and other pentraxin proteins can activate a complement pathway through C1q, collectins, or on
Safaa I Khater et al.
Biomedicines, 10(7) (2022-07-28)
Oxidative stress is considered the main etiologic factor involved in inflammatory bowel disease (IBD). Integration of nanocarriers for natural therapeutic agents with antioxidant and anti-inflammatory potential is a novel promising candidate for curing IBD. Herein, the colonic antioxidant and anti-inflammatory
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