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Merck

SCN2A

sodium channel, voltage-gated, type II, alpha subunit

Synonyme:
BFIC3, BFIS3, BFNIS, EIEE11, HBA, HBSCI, HBSCII, NAC2, Na(v)1.2, Nav1.2, SCN2A1, SCN2A2
Spezies:
UniProtKB-ID:
Gen-ID:
  • Human(6326) Summary: Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. It is heterogeneously expressed in the brain, and mutations in this gene have been linked to several seizure disorders. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
  • chicken(395945) sodium channel, voltage-gated, type II, alpha subunit
  • dog(478773) sodium channel, voltage-gated, type II, alpha subunit
  • Horse(100051816) sodium channel, voltage-gated, type II, alpha subunit
  • domestic cat(101080472) sodium channel, voltage-gated, type II, alpha subunit
  • domestic guinea pig(100716680) sodium channel, voltage-gated, type II, alpha subunit
  • naked mole-rat(101715020) sodium channel, voltage-gated, type II, alpha subunit
  • cow(539718) sodium channel, voltage-gated, type II, alpha subunit
  • sheep(101103126) sodium channel, voltage-gated, type II, alpha subunit

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Small Molecule - Antagonist

Produktnummer
Beschreibung
Spezies
Riluzol, solid,
Spezies
rat, human
Oxcarbazepin, ≥98% (HPLC), solid,
Spezies
rat, human
BIA 2-093, ≥98% (HPLC), solid,
Spezies
rat, human
Lidocain, powder,
Spezies
rat, human
Lamotrigin, ≥98%, powder,
Spezies
rat, human

Antibodies

Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-SCN2A Antibody, clone 5H10.2, clone 5H10.2, from mouse,
Speziesreaktivität
human
Anwendung
western blot
Anti-SODIUM CHANNEL-PAN antibody produced in rabbit, affinity isolated antibody,
Speziesreaktivität
human, mouse, rat
Anwendung
ELISA
immunohistochemistry

western blot
Anti-Sodium Channel Antibody, Voltage Gated, Brain Type II, Chemicon®, from rabbit,
Speziesreaktivität
mouse, rat
Anwendung
immunohistochemistry
western blot
Monoklonaler Anti-Natriumkanal, Pan in Maus hergestellte Antikörper, ~1 mg/mL, clone K58/35, purified immunoglobulin,
Speziesreaktivität
mammals
Anwendung
immunofluorescence
immunohistochemistry

western blot

Small Molecule - Blocker

Produktnummer
Beschreibung
Spezies
Lidocain -hydrochlorid Monohydrat, solid,
Spezies
human
Procain -hydrochlorid, ≥97%,
Spezies
human
Lidocain -hydrochlorid, United States Pharmacopeia (USP) Reference Standard,
Spezies
human
Lidocain, United States Pharmacopeia (USP) Reference Standard,
Spezies
human
Procainamid -hydrochlorid, ≥98% (HPLC),
Spezies
human

esiRNA

Produktnummer
Beschreibung
Spezies
MISSION® esiRNA, targeting mouse Scn2a,
Spezies
mouse
MISSION® esiRNA, targeting human SCN2A,
Spezies
human