ACO1
aconitase 1, soluble
Synonyme:
ACONS, IREB1, IREBP, IREBP1, IRP1
Spezies:
Human ACO1 (48), Mouse Aco1 (11428), Rat Aco1 (50655), Zebrafish aco1 (568448), cow ACO1 (512995), Horse ACO1 (100067866), domestic cat ACO1 (101095526), dog ACO1 (481576), chicken ACO1 (373916), Thale Cress ACO1 (816478) ...Mehr
UniProtKB-ID:
Gen-ID:
- Human(48) Summary: The protein encoded by this gene is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. When the protein binds to IRE, it results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degraded transferrin receptor mRNA. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]
- Mouse(11428) aconitase 1
- Rat(50655) aconitase 1, soluble
- Zebrafish(568448) aconitase 1, soluble
- cow(512995) aconitase 1, soluble
- Horse(100067866) aconitase 1, soluble
- domestic cat(101095526) aconitase 1, soluble
- dog(481576) aconitase 1, soluble
- chicken(373916) aconitase 1, soluble
- Thale Cress(816478) 1-aminocyclopropane-1-carboxylate oxidase 1
- Thale Cress(829737) aconitate hydratase 1
- domestic guinea pig(100720793) aconitase 1, soluble
- naked mole-rat(101716545) aconitase 1, soluble
- sheep(101112791) aconitase 1, soluble
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Antibodies
Produktnummer
Beschreibung
Speziesreaktivität
Anwendung
Anti-ACO1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab1,
Speziesreaktivität
human, mouse, rat
Anwendung
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-ACO1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab2,
Speziesreaktivität
human
Anwendung
immunohistochemistry
Anti-Iron Pegulatory Protein 1 Antibody, Chemicon®, from rabbit,
Speziesreaktivität
rat
Anwendung
ELISA
western blot
western blot
Anti-ACO1 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Speziesreaktivität
human
Anwendung
western blot
Monoclonal Anti-ACO1 antibody produced in mouse, clone 2C1, purified immunoglobulin, buffered aqueous solution,
Speziesreaktivität
human
Anwendung
ELISA
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot